FIELD: pharmaceutical industry.
SUBSTANCE: method for granulation of non-dehydrated azitromicine includes mixing of non-dehydrated azitromicine particles with granulating amount of non-aqueous granulating liquid followed by drying of wet granules to remove non-aqueous granulating liquid. Non-dehydrated azitromicine is selected from group containing from hemi-ethanol solvate of azitromicine monohydrate, hemi-n-propanol solvate of azitromicine monohydrate, azitromicine sesquihydrate, and hemi-isopropanol solvate of azitromicine monohydrate. Also disclosed are pharmaceutical compositions containing granules of non-dehydrated azitromicine and method for treatment of protosoal or bacterial infections in mammalian by administration of said pharmaceutical composition.
EFFECT: granules of non-dehydrated azitromicine with improved quality.
10 cl, 8 tbl, 9 ex
