FIELD: chemistry.
SUBSTANCE: claimed invention relates to macrolide derivative, namely to hydrate of erythromycin salts, which has molecular formula C37H67NO13·A·nH2O, n=1, 5; 2; 3; 3.5; 5; 6 or 11, where A represents lactobionic acid or thiocyanic acid, with n=3; 3.5; 5; 6 or 11, if A is lactobionic acid and n=1.5; 2 or 3, if A represents thiocyanic acid. Hydrate possesses good water solubility and better stability in storage, which is convenient for production of medication for treatment and prevention in people and animals of infectious diseases caused by bacteria, mycoplasms or chlamydia, sensitive to erythromycin. Also claimed is method of obtaining hydrate of erythromycin salts and its application for preparation or purification of erythromycin.
EFFECT: obtaining pharmaceutical composition, possessing antibacterial activity.
14 cl, 20 ex, 12 tbl, 7 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| HEXANONE COMPOUNDS AND USING THEM IN MEDICAL APPLICATIONS | 2011 |
|
RU2553668C2 |
| BROMOPHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES | 2008 |
|
RU2443703C2 |
| DYETERED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH CONNECTIONS | 2014 |
|
RU2632907C2 |
| MONOHYDRATE CRYSTAL OF FIMASARTAN POTASSIUM SALT, METHOD FOR PREPARING SAME, AND PHARMACOLOGICAL COMPOSITION COMPRISING SAME | 2013 |
|
RU2613555C2 |
| THIENOPYRIDINE ESTER DERIVATIVE, CONTAINING CYANOGROUP, METHOD OF ITS OBTAINING, ITS APPLICATION AND BASED ON IT COMPOSITION | 2011 |
|
RU2526624C2 |
| SYNTHETIC IMMUNE PROTECTION MIMETICS AND USE THEREOF | 2009 |
|
RU2540077C2 |
| DEUTERATED QUINAZOLINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 2015 |
|
RU2656485C2 |
| SALTS AND SOLID FORMS OF MONOBACTAM ANTIBIOTIC | 2016 |
|
RU2754180C2 |
| LEVOROTATORY ISOVALERYLSPIRAMYCIN 1, II, III, PREPARATIONS, METHOD FOR PREPARATION AND USE | 2011 |
|
RU2593498C2 |
| MEDICINE, REPRESENTING A CONJUGATE WITH POLYETHYLENE GLYCOL, METHOD FOR ITS PREPARATION AND ITS APPLICATION | 2020 |
|
RU2805370C1 |
