METHOD FOR CHOOSING THERAPEUTIC TACTICS IN CASE OF CHRONIC AND ACUTE RHINOSINUSITIS Russian patent published in 2005 - IPC

FIELD: medicine, otorhinolaryngology.

SUBSTANCE: the present innovation deals with treating diseases of the upper respiratory tract. One should detect disorders of mucociliary transport (MCT) due to measuring the motor parameters of ciliated epithelium cilia, at least, the rate of mucociliary transport that includes material sampling for further testing as ciliary epithelial cells and registration of cilia fluctuations in human respiratory tract due to TV microscopy performed in patient's lifetime. Material for testing should be sampled from mucosal surface of respiratory tract, and therapeutic tactics should be chosen depending upon motor velocity of cilium's tip obtained based upon mathematical modeling followed by calculations by the formula: , where V_c - velocity of cilium's tip [mcm*sec¹]; C₁, C₂, α - calculated as average values being characteristic for every of human body states under investigation: healthy persons, patients with either acute or chronic forms of sinusitis by the developed model of cilia movement; C₁ - curvature of cilium's working length, constant being equal to 1/38 mcm^-1; C₂ - cilium's curvature from its working length up to the tip [mcm^-1]; α - cilium's inclination angle against vertical position [degrees]; π = 3.1417 - constant; L, T_s and T_e - parameters measured individually in every patient; L - cilium's length [mcm]; T_s - time from the onset of movement till maximal straightening of cilium's tip [sec]; T_e - time of efficient impact [sec]. Moreover, the value being V_c = 9.6 - 11.3 mm/min corresponds to normal MCT functioning. For patients with chronic purulent sinusitis beyond exacerbation accompanied with MCT disorder it is necessary to prescribe complex therapy: surgical or conservative therapy with preparations of secretolytic and secretomotory action. For patients with chronic purulent sinusitis beyond exacerbation without any MCT disorder one should prescribe surgical therapy. All patients with acute sinusitis with MCT disorder should be prescribed complex conservative therapy with preparations of secretolytic and secretomotory action. The method enables to specify optimal therapy based upon scientifically proved indications of investigations by taking into account individual peculiarities of every patient.

EFFECT: higher efficiency.

5 dwg, 3 ex, 2 tbl