STABLE PHARMACEUTICAL AZITHROMYCIN SUSPENSION AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

FIELD: medicine, pharmacy, pharmaceutical technology.

SUBSTANCE: invention relates to an antibacterial preparation azithromycin. The stable pharmaceutical suspension of azithromycin comprises the therapeutically effective dose of azithromycin and special additives - sorbitol, sodium benzoate, aromatic principles, glycerol, glutamic acid, methylcellulose, polyvinylpyrrolidone and propylene glycol. Also, invention proposes a method for preparing the stable suspension of azithromycin that involves addition of mixture of azithromycin with glutamic acid as solution in glycerol or as dry form to an aqueous solution of methylcellulose containing propylene glycol and glycerol or propylene glycol and successively dissolved sodium benzoate, polyvinylpyrolidone and sorbitol followed by dilution with water up to the azithromycin concentration that is necessary for using. Invention provides creature of new stable suspension that is resistant for 1 year, not less, and useful for treatment of children being among them suffering with diabetes mellitus.

EFFECT: improved method for preparing, valuable medicinal properties of suspension.

4 cl, 4 tbl, 1 dwg, 4 ex