FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to derivatives of N-desacetylthiocolchicine of the formula (I):
wherein n represents a whole number from 0 to 8; Y represents group CH2 or if n = 1 then can mean group NH also. These compounds elicit an anti-proliferative activity. Also, invention describes pharmaceutical composition based on compounds of the formula (I).
EFFECT: valuable medicinal properties of derivatives.
4 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONDENSED DERIVATIVES OF THIOCOLCHICINE AND BACCATIN AS ANTITUMOR AGENTS | 2001 |
|
RU2264393C2 |
| DERIVATIVES OF COLCHICINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 1997 |
|
RU2181354C2 |
| N-DEACETYLTHIOCOLCHICIN DERIVATIVES, THEIR APPLICATION AND PHARMACEUTICAL COMPOSITIONS | 2005 |
|
RU2370486C2 |
| DERIVATIVES OF THIOCOLCHICINE, METHODS OF THEIR SYNTHESIS, COMPOUND, PHARMACEUTICAL COMPOSITION | 1998 |
|
RU2190598C2 |
| PROCESS FOR PREPARING DERIVATIVES OF TRIPEPTIDES | 0 |
|
SU1034603A3 |
| OXAZOLIDINONE-QUINOLONE-HYBRID ANTIBIOTICS | 2004 |
|
RU2371443C2 |
| METHOD FOR PREPARING 1,3-OXATHIOLAN NUCLEOSIDE, METHOD FOR PREPARING DERIVATIVE OF 1,3-OXATHIOLANYL-5-ONE | 1999 |
|
RU2244712C2 |
| MONOCYCLIC L-NUCLEOSIDES, THEIR ANALOGUES AND USING | 1997 |
|
RU2188828C2 |
| COMBINATION OF REUPTAKE INHIBITOR OF 5-HT WITH SELECTIVE 5-HT ANTAGONIST | 1996 |
|
RU2183955C2 |
| 0 |
|
SU957762A3 |
