FIELD: organic chemistry, medicine, oncology.
SUBSTANCE: invention relates to derivatives of N-desacetylthiocolchicine and 10-desacetylbaccatin III of the formula (I):
wherein R and n have values given in description. These compounds are valuable antitumor medicinal agents. Also, invention relates to a pharmaceutical composition based on compounds of the formula (I) and possessing an anti-proliferative activity. Invention provides preparing new derivatives of 10-desacetylbaccatin III possessing a valuable pharmaceutical effect.
EFFECT: valuable medicinal property of compounds.
5 cl, 5 ex
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