FIELD: biotechnology, medicine.
SUBSTANCE: Zalpha 11-ligand is isolated from cDNA library generated from activated cells of human peripheral blood that have been selected from CD3. Animal is inoculated with Zalpha 11-ligand and antibodies are prepared that are able to bind specifically with epitopes, peptides or polypeptides of Zalpha 11-ligand. Invention provides effective regulation and/or development of hemopoietic cells in vitro and in vivo. Invention can be used for preparing Zalpha 11-ligand and antibodies for it.
EFFECT: valuable properties of new cytokine.
18 cl, 5 tbl, 1 dwg, 55 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW LIGAND OF CYTOKINE RECEPTOR ZCYTOR17 | 2003 |
|
RU2490276C2 |
| ISOLATED SOLUBLE IL-20 RECEPTOR (VARIANTS) | 2000 |
|
RU2279441C2 |
| INTERFERON-LIKE PROTEIN ZCYTO21 | 2001 |
|
RU2292394C2 |
| HEMOPOIETIC PROTEIN (VARIANTS), DNA SEQUENCE, METHOD FOR PREPARING HEMOPOIETIC PROTEIN, METHOD FOR SELECTIVE EXPANSION OF HEMOPOIETIC CELLS, METHOD FOR PRODUCING DENDRITIC CELLS, METHOD FOR STIMULATING FOR PRODUCING HEMOPOIETIC CELLS IN PATIENT, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT | 1997 |
|
RU2245887C2 |
| MODIFIED ANTAGONISTIC ANTIBODY | 2001 |
|
RU2295537C2 |
| POLYPEPTIDE WITH ANTIVIRAL ACTIVITY, ITS PRODUCTION AND USE | 2004 |
|
RU2372356C2 |
| HOMOGENOUS PREPARATIONS OF IL-28 AND IL-29 | 2004 |
|
RU2518324C2 |
| MONOCLONAL ANTIBODIES AGAINST IL-21 OF HUMAN BEING | 2008 |
|
RU2504552C2 |
| DEGRADED ANTIBODY AS TPO AGONIST | 2001 |
|
RU2287534C2 |
| ISOLATED NUCLEIC ACID ENCODING FELINE LIGAND CD86, DIAGNOSTIC OLIGONUCLEOTIDE, CLONING VECTOR, VACCINE, METHODS FOR INDUCTION OR SUPPRESSION OF IMMUNITY IN CAT | 1999 |
|
RU2263145C2 |
