NEW HETEROCYCLIC COMPOUNDS AS PHARMACEUTICALS Russian patent published in 2005 - IPC

Abstract RU 2260009 C2

FIELD: pharmaceutical chemistry, medicine.

SUBSTANCE: present invention relates to new heterocyclic derivatives having calpain inhibition activity or oxygen reactive form recovering entrapping activity of formula I

1, wherein Het represent monocyclic 5-6-membered hetericyclic radical containing 1-2 heteroatoms selected from O or N; A represents A1

2, A'1 3, A2 4, A3 5 and A4 6; X represent -(CH₂)_n-, -(CH₂)_n-CO-, -N(R⁴⁵)-CO-(CH₂)_n-CO, -CO-N(R⁴⁵)-D-CO-, -N(R⁴⁵)-(CH₂)_n-CO-, -N(R⁴⁵)-CO-C(R⁴⁶R⁴⁷)-CO-, -O-(CH₂)_n-CO-, -N(R⁴⁵)-CO-NH-C(R⁴⁶R⁴⁷)-CO-, -CO-N(R⁴⁵)-C(R⁴⁶R⁴⁷)-CO- or -Z-CO Y represents -(CH₂)_p-, C(R⁵³R⁵⁴)-(CH₂)_p-, C(R⁵³R⁵⁴)-CO-; R¹ represents hydrogen, group CR³ or oxo; R³ represents hydrogen, monocyclic saturated 6-membered heterocycloalkylcarbonyl, wherein heterocycle contains two heteroatoms selected from nitrogen or oxygen, C1-C6-alkylcarbonyl, phenylcarbonyl or phenyl(C1-C6)-alkylcarbonyl optionally substituted with NR⁴R⁵, or R⁴and R⁵ independently represent C1-C6-alkyl; R² represents hydrogen, and pharmaceutical compositions containing the same.

EFFECT: new heterocyclic drugs.

18 cl, 37 ex

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RU 2 260 009 C2

Authors

Ovehn Serzh

Shabrie De Lasson'Er P'Er-Eht'Enn

Dates

2005-09-10—Published

2000-11-03—Filed