DERIVATIVES OF 6-MERCAPTOCYCLODEXTRIN: REVERSING AGENTS FOR DRUG- INDUCED NEUROMUSCULAR BLOCKADE Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention describes a derivative of 6-mercaptocyclodextrin of the general formula (I):

wherein n = 0-7; n = 1-8 and m + n = 7 or 8; R represents (C₁-C₆)-alkylene substituted optionally with 1-3 OH-groups, or (CH₂)_o-phenylene-(CH₂)_p wherein o and p = 0-4 independently; X represents COOH, CONHR₁, NHCOR₂, SO₂OH, PO(OH)₂, O(CH₂-CH₂-O)_q-H, OH or tetrazole-5-yl; R₁ represents hydrogen atom (H) or (C₁-C₃)-alkyl; R₂ represents carboxyphenyl; q = 1-3; or its pharmaceutically acceptable salt in mixture with pharmaceutically acceptable accessory substances. Also, invention describes a set and pharmaceutical composition for reversing drug-induced neuromuscular blocking comprising derivative of 6-mercaptocyclodextrin of the general formula (I), and a method for reversing drug-induced neuromuscular blockade in patient that involves parenteral administration to indicated patient the effective dose of 6-mercaptocyclodextrine derivative of the general formula (I) by cl. 1.

EFFECT: valuable medicinal properties of agents.

11 cl, 1 tbl, 20 ex