METHOD FOR PREDICTING OSSEOUS FRACTURES IN RHEUMATOID ARTHRITIS-SUFFERING WOMEN Russian patent published in 2005 - IPC

FIELD: medicine, therapy, rheumatology.

SUBSTANCE: one should detect mineral density of bony tissue in lumbar vertebral department, in column femoris; from patient's life anamnesis one should detect risk factors for osseous fractures: duration of menopause, duration and index of disease severity degree, systemic manifestations of rheumatoid arthritis (RA), solitude, dosage and duration for the intake of glucocortico-steroid (GCS) preparations to establish their gradations and digital values: no risk factor - the sign has got digital value "0", if risk factor is available - "1". Then it is necessary to detect prognostic coefficients F₁ and F₂ by the following formulas: F₁ = -38.72 - 7.27*X₁ + 9.77*X₂ + 6.30*X₃ +4.25*X₄ + 7.41*X₅ + 9.66*X₆ + 32.97*X₇ + 3.62*X₈ + 8.96*X₉ + 38.04*X₁₀ - 0.55*X₁₁ - 0.50*X₁₂; F₂ = -5.41 - 4.32*X₁ + 3.22*X₂ + 2.91*X₃ + 3.28*X₄ + 3.24*X₅ +3.93*X₆ + 7.43*X₇ +1.35*X₈ + 1.08*X₉ + 9.07*x₁₀ - 0.11*X₁₁ - 0.19*X₁₂, where X_1-12 - gradations and digital values of risk factors (X₁ - age is above 45, X₂ - postmenopause is above 5 years, X₃ - RA duration is above 10 years, X₄ - severity degree index is above 5 points, X₅ - RA systemic manifestations, X₆ - solitude, X₇ - intake of GCS preparations is above 2 years, X₈ - cumulative dosage of GCS is above 5000 mg, X₉ - mineral density of bony tissue in lumbar vertebral department by T-criterion is below -2.5, X₁₀ - mineral density of bony tissue in collum femoris by T-criterion is below -2.5, X₁₁ - mineral density of bony tissue in collum femoris is below 0.700 g/sq. cm, X₁₂ - mineral density of bony tissue in lumbar vertebral department is below 0.900 g/sq. cm). At F1≥F2 one should predict high risk for fracture possibility, and at F1<F2 - low risk for fracture chance. The innovation enables to take into consideration the sum of common and specific risk factors.

EFFECT: higher accuracy of prediction.

4 ex, 1 tbl