FIELD: organic chemistry, medicine, pharmacology.
SUBSTANCE: invention relates to compounds of the formula (I):
and their pharmaceutically acceptable salts wherein R1 means hydrogen (H), chlorine or bromine atom; R2 means electron-acceptor groups -CF3, -CN, fluorine atom, -COSO3H, -CF3SO3 and -NO2; R3 means linear or branched alkyl comprising from 2 to 10 carbon atoms, linear or branched alkoxyalkyl, aliphatic alcohol comprising from 1 to 10 carbon atoms or cycloalkyl comprising from 3 to 6 carbon atoms. Also, invention relates to methods for preparing indicated compounds and to a pharmaceutical composition comprising thereof. Compounds of the present invention are agonists of β2-receptor and can be used in treatment of asthma and bronchitis.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
9 cl, 1 tbl, 48 ex
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