METHOD FOR PURIFYING FERMENTATION BROTH Russian patent published in 2005 - IPC

Abstract RU 2265665 C2

FIELD: biotechnology, pharmacy.

SUBSTANCE: statin compounds from fermentation solution are purified by extraction and crystallization. Fermentation broth is subjected for preliminary treatment that involves preliminary alkaline treatment followed by extraction of nonpolar impurities. After preliminary treatment the statin compound is extracted into hydrophobic solvent that is separated after extraction. Then solution of hydrophobic organic solvent is concentrated and washed out, if necessary, with a base-containing aqueous solution. Then extracted statin compound is purified by crystallization. Invention provides isolating statins from fermentation broth with high degree of effectiveness and under pharmaceutically acceptable level of purity.

EFFECT: improved purifying method.

28 cl, 8 ex

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RU 2 265 665 C2

Authors

Keri Vilmosh

Deak Lajosh

Forgach Ilona

Dates

2005-12-10Published

2001-01-25Filed