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(19)

(11)

2 260 582

(13)

(51)

IPC

(21) (22)

Application

2003110580/04, 2001-10-15

(24)

Start date

2001-10-15

(22)

Actual filing date

2001-10-15

(45)

Published

2005-09-20

(72)

Inventor

Sugio NobunariTakamatsu JasujukiKodzima SunsiSuzuki MutsuoKhagisava MinoruKhamano Kijosi

(73)

Holder

Sankio Kompani, Limited

METHOD FOR PURIFYING PRAVASTATIN Russian patent published in 2005 - IPC

Abstract RU 2260582 C2

FIELD: organic chemistry, chemical technology, pharmacy.

SUBSTANCE: invention relates to the improved method for isolating and purifying pravastatin or its pharmacologically acceptable salt from impurities of pravastatin analogues. Method involves extraction of pravastatin or its pharmacologically acceptable salt comprising impurities of pravastatin analogues with organic solvent of the formula: CH₃CO₂R wherein R represents alkyl comprising 3 or 4 carbon atoms. Also, invention relates to the improved method for isolating or purifying pravastatin or its pharmacologically acceptable salt that involves decomposition of impurities by using inorganic acid or that involves removing compound of the formula (I): by using inorganic solvent. Also, invention relates to the composition comprising pravastatin sodium salt and compound of the formula (I) taken in the amount 0.1 wt.-% or less with respect to the amount of pravastatin sodium salt. Method provides preparing the end product of the high purity degree.

EFFECT: improved purifying method.

18 cl, 1 tbl, 8 ex

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RU 2 260 582 C2

Authors

Sugio Nobunari

Takamatsu Jasujuki

Kodzima Sunsi

Suzuki Mutsuo

Khagisava Minoru

Khamano Kijosi

Dates

2005-09-20—Published

2001-10-15—Filed