METHOD FOR PREPARING STATIN SODIUM SALTS Russian patent published in 2005 - IPC

Abstract RU 2246481 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to a method for preparing statin sodium salts that relate to enzyme inhibitors that inhibit biosynthesis of plasma cholesterol of different species of mammals and can be used in preparing medicinal preparations. Method involves preparing statin sodium salts of the general formula: , wherein R represents hydrogen atom (H), CH3 or OH. Method involves interaction of statins as an oxyacid with the stoichiometric amount of 2-ethylhexanoate sodium to obtain suspension. Statin sodium salts are prepared from this suspension by filtration and drying a precipitate in the form of dry powder. Invention provides preparing such statin sodium salts as compactin, lovastatin and pravastatin sodium salts.

EFFECT: improved preparing method.

11 cl, 5 ex

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RU 2 246 481 C2

Authors

Narula Pardip

Raman S.

Kumar M. Lakshmi

Kumar Parvin

Dates

2005-02-20Published

2000-12-14Filed