NEW ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, THEIR SALTS AND METHOD FOR PREPARING THESE COMPOUNDS Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to acyclic nucleoside phosphonate derivatives of the formula (1): wherein means a simple or double bond; R¹ means hydrogen atom; R² and R³ mean hydrogen atom or (C₁-C₇)-alkyl; R⁷ and R⁸ mean hydrogen atom or (C₁-C₄)-alkyl; R⁴ and R⁵ mean hydrogen atom or (C₁-C₄)-alkyl possibly substituted with one or more halogen atoms, or -(CH₂)_m-OC(=O)-R⁶ wherein m means a whole number from 1 to 5; R⁶ means (C₁-C₇)-alkyl or 3-6-membered heterocycle comprising 1 or 2 heteroatoms taken among the group consisting of nitrogen (N) and oxygen (O) atoms; Y means -O-, -CH(Z)-, =C(Z)-, -N(Z)- wherein Z means hydrogen atom, hydroxy-group or halogen atom, or (C₁-C₇)-alkyl; Q (see the claim invention); its pharmaceutically acceptable salts or stereoisomers. Also, invention proposes methods for preparing compounds of the formula (1) and their using in treatment of hepatitis B or preparing a medicinal agent designated for this aim.

EFFECT: improved preparing method, valuable medicinal properties of compounds and agent.

16 cl, 10 tbl, 87 ex