FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention proposes (aminopropyl)methylphosphinic acids of the general formula (I): 
with exception of the following compounds: (1) (3-amino-2-hydroxypropyl)methylphosphinic acid racemate; (2) (S)-(3-amino-2-hydroxypropyl)methylphosphinic acid; (3) (R)-(3-amino-2-hydroxypropyl)methylphosphinic acid; (4) (3-amino-2-hydroxypropyl)difluoromethylphosphinic acid, and (5) (3-amino-2-oxopropyl)methylphosphinic acid showing affinity to one or more GABAe (γ-aminobutyric acid) receptor. Also, invention proposes their pharmaceutically acceptable salts, solvates and stereoisomers, and pharmaceutical compositions comprising indicated therapeutically active compounds and using indicated compounds for aims of therapy.
EFFECT: valuable medicinal properties of compounds and compositions.
12 cl, 15 ex
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