SYNTHETIC INTERMEDIATE COMPOUND 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE THIONUCLEOSIDES COMPOUND AND METHOD FOR THEIR PRODUCTION Russian patent published in 2017 - IPC C07C251/38 C07C47/19 C07C47/277 C07C249/04 C07C303/28 C07H5/02 C07H5/10 C07H19/06 A61K31/7068 A61P35/00 

Abstract RU 2633355 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a process for preparation of a compound of the formula and also to a process for the preparation of 1-(2-desoxy-2-halo-4-thio-β-D-arabinofuranosyl) cytosine of the following formula: . In addition, the invention relates to a formula intermediate.

EFFECT: new method for preparation of thionucleoside, which is useful as a medicament, is developed.

24 cl, 48 ex

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RU 2 633 355 C2

Authors

Nakamura Kouki

Simamura Satosi

Imoto Dzuniti

Takakhasi Motomasa

Vatanabe Katsuyuki

Vada Kendzi

Fudzino Yuuta

Matsumoto Takuya

Takakhasi Makoto

Okada Khideki

Yamane Takekhiro

Ito Takayuki

Dates

2017-10-12Published

2013-08-13Filed