METHOD FOR DECREASING CERAMIDE CONTENT, SET COMPRISING ANTIRETROVIRAL MEDICINAL AGENT Russian patent published in 2006 - IPC A61K31/205 A61K31/7072 A61P31/18 

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to treatment of HIV-infection and AIDS and involves a method for decreasing the content of ceramides in a patient suffering these diseases and a set for its realization. Method involves administration in a patient the medicinal preparation comprising L-carnitine or acyl-L-carnitine wherein a linear or branched acyl group comprises 2-6 carbon atoms, or their pharmacologically acceptable salts in combination with an antiretroviral medicinal preparation taken among the group of nucleoside-like inhibitors of reverse transcriptase, non-nucleoside inhibitors of reverse transcriptase, inhibitors of HIV protease. A set for decreasing the content of the content of ceramides involves an antiretroviral medicinal agent taken among the abovementioned group and enhancing agent taken among the group consisting of L-carnitine or acyl-L-carnitine wherein linear or branched acyl group comprises 2-6 carbon atoms, or their pharmacologically acceptable salts or mixtures. Invention provides enhancing activity of antiretroviral agents and to protect immune system due to decreasing the concentration of ceramides that results to inhibition of HIV expression and cellular apoptosis.

EFFECT: improved and valuable medicinal properties of agent.

20 cl, 2 tbl, 2 ex