INGENOL DERIVATIVES FOR REACTIVATION OF LATENT HIV VIRUS Russian patent published in 2017 - IPC A61K31/22 A61K31/122 A61K31/47 A61K31/232 A61K45/06 A61P31/18 C08G8/30 

FIELD: chemistry.

SUBSTANCE: present invention relates to use certain ingenol derivatives as reactivators of latent HIV virus in viral reservoirs. In particular, invention relates to use of one or more ingenol derivatives of formula I in obtaining a product for reactivation of latent HIV virus in viral reservoirs of human body, where Z is Z1 or Z2

so that when Z = Z1, x and y are integers, x varies from 2 to 10 and y varies from 2 to 7; and when Z = Z2, A is phenyl, CH₃- or CH₂=CH- and B represents -CH=CH-, [-CH₂-]_q or [-CH₂-]_w, where q is an integer ranging from 1 to 10 and w is an integer ranging from 1 to 10, provided that: if A is phenyl, B is -CH=CH-; if A is CH₃-, B is [-CH₂-]_q; if A is CH₂=CH-, B is [-CH₂-]_w, and provided that ingenol derivative of formula (I) does not include 3-(2,4,6-dodecatrienoyl)-ingenol or 3-(2,4,6,8-tetradecatetranoyl)-ingenol.

EFFECT: in another aspect, present invention relates to a combination including said ingenol derivatives and antiretroviral agents, which exhibit considerable activity against actively replicating virus.

11 cl, 12 dwg, 11 ex