FIELD: medicine, endocrinology, biochemistry, peptides.
SUBSTANCE: invention represents new peptides that act in vivo as stimulators of insulin secretion by pancreas beta-cells in glucose-dependent regimen. Such peptides as enhancers of insulin secretion stimulate insulin secretion by insula cells in rats in vitro and in vivo. Proposed peptides represent a new way for treatment of patients with reduced secretion of endogenous insulin, in particular, for treatment of diabetes mellitus type 2. In particular, invention represents polypeptide taken among the specific group VIP/PACAP-related polypeptides or their functional equivalents. Also, invention claims method for preparing both recombinant and synthetic peptides. The advantage of invention involves new peptides that can be used as stimulators of insulin secretion.
EFFECT: improved and valuable medicinal properties of peptides.
47 cl, 4 tbl, 10 dwg, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEUROPEPTIDES FOR CULTURE OF AQUATIC ORGANISMS | 2006 |
|
RU2409027C2 |
| HOST CELLS AND WAYS TO USE | 2014 |
|
RU2663587C2 |
| GENE SET EXPRESSION INCLUDING sORF CONSTRUCTS AND METHODS FOR IMMUNOGLOBULIN EXPRESSION | 2006 |
|
RU2478709C2 |
| METHOD TO PRODUCE RECOMBINANT ANTI-ANGIOGENIC POLYPEPTIDE | 2012 |
|
RU2488635C1 |
| SIGNAL PEPTIDES TAT FOR PRODUCTION OF PROTEINS IN PROCARYOTES | 2008 |
|
RU2487937C2 |
| MICROBIOLOGICAL SYNTHESIS METHOD OF TARGET RELEASED PROTEIN IN YEAST Saccharomyces cerevisiae | 2012 |
|
RU2502805C1 |
| COMPOSITIONS AND METHODS RELATED TO SOLUBLE G-PROTEIN CONJUGATE RECEPTORS (SGPCR) | 2006 |
|
RU2423378C2 |
| DPPIV-COGNATED NEW SERINE PROTEASE GENE | 2001 |
|
RU2305133C2 |
| OBESITY POLYPEPTIDE (OB) (VARIANTS), ITS ANALOGUE (VARIANTS), AND FUSED PROTEIN (VARIANTS), NUCLEIC ACID ISOLATED MOLECULE, DNA MOLECULE, CLONING RECOMBINANT VECTOR, EXPRESSION RECOMBINANT VECTOR, PHARMACEUTICAL COMPOSITION, MONOCLONAL AND POLYCLONAL ANTIBODY | 1995 |
|
RU2273645C9 |
| FUSED DRUG CONSTRUCTS AND CONJUGATES | 2005 |
|
RU2428431C2 |
