METHOD OF PREPARING MACROCYCLES WITH ALTERNATE ALKA-1Z,5Z-DIENE FRAGMENTS Russian patent published in 2006 - IPC C07C13/02 C07C2/42 

FIELD: organic synthesis.

SUBSTANCE: invention proposes synthesis of novel macrocycles with alternate alka-1Z,5Z-diene fragments having general formula 1: where R represents (CH₂)₄, (CH₂)₅, or (CH₂)₆ and n = 3-5, which synthesis comprises reaction of α,ω-diallenes of general formula =•=-R-=•=, wherein R is as above, with ethylmagnesium bromide and magnesium powder at molar ratio 10:(10-14):(5-7), respectively, in presence of titanacene dichloride (Cp₂TiCl₂) catalyst used in amount 0.3-0.7 mmol per 1 mole α,ω-diallene. Reaction proceeds in tetrahydrofurane under nitrogen atmosphere at ambient temperature during 8-12 h. Macrocycles may find use in synthesis of biologically active compounds as well as in perfume industry.

EFFECT: expanded synthetic possibilities in macrocycle chemistry.

1 tbl, 11 ex