FIELD: medicine; animal breeding; medicine; fragrance industry; methods of production of the highest cycloalkanes.
SUBSTANCE: the invention is pertaining to methods of production of the new saturated cyclooligomeric hydrocarbons and may be applied in the synthesis of the biologically active preparations in medicine and animal breeding, and also in the fragrance industry. The method provides, that exercise the interaction of α, ω-dipropadienes with ethylmagnesiumbromide and magnesium (powder) at presence of titaniumcoendichloride as the catalyst in the argon atmosphere in THF with the subsequent hydrolysis of the reaction mass and hydrogenation of the being formed unsaturated macrocycle with the help of the molecular hydrogen on Pd/C in hexane solution. The total output of the target products makes 73-95 percent.
EFFECT: the invention ensures the total output of the target products about 73-95 percent.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PREPARING MACROCYCLES WITH ALTERNATE ALKA-1Z,5Z-DIENE FRAGMENTS | 2004 |
|
RU2269505C1 |
| METHOD FOR PREPARING CYCLOOLIGOMERIC 2-METHYLIDENE-5-ALKYLIDENE MAGNESIUM-CYCLOPENTANES | 2004 |
|
RU2268265C1 |
| METHOD FOR PRODUCTION OF 4,7-DIALKYL(BENZYL)IDEN-1,9-DECADIENS | 2005 |
|
RU2283827C1 |
| METHOD FOR PREPARING 1,6-DIALKYL-2,5-BIS-(ETHYLMAGNESA)-1,5-HEXADIENES | 2003 |
|
RU2238942C1 |
| METHOD OF PRODUCING 2,3-DIALKYL-5-ALKYLIDENEMAGNESA-CYCLOPENT-2-ENES | 2006 |
|
RU2374255C2 |
| METHOD OF PRODUCING 11-MAGNESATRICYCLO[10.7.0.0]NONADECA-9,12-DIENE | 2008 |
|
RU2375364C2 |
| METHOD FOR PREPARING 4,7-DIALKYL(BENZYL)IDENE-2,10-DODECADIENES | 2005 |
|
RU2286328C1 |
| METHOD FOR PRODUCTION OF 2,9-DIMETHYL-4,7-DIALKYL(BENZYL)IDEN-1,9-DECADIENS | 2005 |
|
RU2283828C1 |
| 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-TETRADECAHYDRO-DICYCLONONE[b,d]THIOPHENE SYNTHESIS METHOD | 2008 |
|
RU2398772C2 |
| METHOD FOR PRODUCTION OF 3,6-DIMETHYL-1,8-DIALKYL(PHENYL)-2,6-OCTADIENS | 2005 |
|
RU2283826C1 |
