NEW CRYSTALLINE FORMS OF 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1-HYDOXYBUTHYL-α, α-DYMETHYLBENZENEACETIC ACID AND HYDROCHLORIDE THEREOF AND METHOD FOR PRODUCTION THE SAME Russian patent published in 2006 - IPC C07D211/22 A61K31/445 A61P11/00 A61P37/00 

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to new crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydoxybuthyl1-dymethylbenzeneacetic acid (), more particularly, to new form of A-phexophenadine having the next powder X-ray pattern (d, E): 23.11; 11.50; 8.29; 7.03; 6.67; 6.16; 6.02; 5.75; 5.43; 5.33; 5.07; 4.69; 4.63; 4.44; 4.20; 4.15; 4.07; 3.55;4.44; as well as to crystalline form of X-phexophenadine hydrochloride, having the next powder X-ray pattern (d, E): 16.05; 12.98; 8.29; 8.06; 6.25; 5.97; 5.54; 5.41; 4.89; 4.70; 4.55;4.37; 4.32; 4.15; 4.03; 3.80; 3.67; 3.57; 3.42; and to methods for production thereof. New crystalline phexophenadine forms of high purity (content of one isomer is higher than 99.5 %) are manufactured with essentially quantitative yield and are useful as antihistamine and antiallergic agents.

EFFECT: new phexophenadine forms useful as antihistamine and antiallergic agents.

18 cl, 10 dwg, 2 tbl, 5 ex