FIELD: chemistry.
SUBSTANCE: novel water-free crystalline hydrochloride of 4-[4-[4-(hydroxydiphenylmethyl)-1-pyperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid (fexofenadine) of form C is different in that it has diffraction band roentgenogram with characteristic peaks (2θ): 8.9712°, 14.8293°, 16.0514°, 17.0775°, 18.3418°, 19.3099°, 19.7703°, 21.1340°, 21.5207°, 23.0743° and 23.8286°. Invention also relates to pharmaceutically acceptable composition for antihistamine treatment as well as to methods of obtaining water-free crystalline hydrochloride of 4-[4-[4-(hydroxydiphenylmethyl)-1-pyperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid (fexofenadine) of form C.
EFFECT: obtaining novel fexofenadine polymorphs, which are useful antihistamine medication.
25 cl, 5 ex, 9 dwg
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