METHOD OF PRODUCING 4-(4-BROMO-2-FLUOROANILINO)-6-METHOXY-7(1-METHYLPIPERIDIN-4YLMETHOXY)QUINAZOLINE (ZD6474) AND METHODS OF PRODUCING INTERMEDIATE COMPOUNDS FOR PRODUCING SAID COMPOUND Russian patent published in 2012 - IPC C07D401/12 C07D239/94 C07D211/16 

Abstract RU 2448102 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 4-(4-bromo-2-fluoroanilino)-6-methoxy-7(1-methylpiperidin-4ylmethoxy)quinazoline having the formula given below, and salts thereof, from compounds of formula X The invention also relates to a method of producing an intermediate compound of formula X and salts thereof, as well as to methods of producing other defined intermediate compounds which are suitable for producing (ZD6474).

EFFECT: high efficiency of the compounds.

25 cl, 1 dwg, 2 tbl, 19 ex

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RU 2 448 102 C2

Authors

Blikst Jergen

Golden Majkl Dejvid

Khougan Filip Dzhon

Martin Dejvid Majkl Glanvill

Montgomeri Fransis Dzhozef

Pejtel Zakarija

Pittam Dzhon Dejvid

Sipenda Dzhordzh Dzhozef

Skvajer Kristofer Dzhon

Rajt Nikolas Kartrajt Aleksander

Dates

2012-04-20Published

2006-09-27Filed