FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 4-(4-bromo-2-fluoroanilino)-6-methoxy-7(1-methylpiperidin-4ylmethoxy)quinazoline having the formula given below, and salts thereof, from compounds of formula X The invention also relates to a method of producing an intermediate compound of formula X and salts thereof, as well as to methods of producing other defined intermediate compounds which are suitable for producing (ZD6474).
EFFECT: high efficiency of the compounds.
25 cl, 1 dwg, 2 tbl, 19 ex
Title |
Year |
Author |
Number |
CHEMICAL METHOD |
2007 |
- Arnott Juan Aleksander
- Krosbi Dzhon
- Ehvans Matt'Ju Charlz
- Ford Dzhejms Gejr
- Dzhouns Martin Fransis
- Lesli Kevin Uill'Jam
- Makfarlejn Ajan Majkl
- Sipenda Dzhordzh Dzhozef
|
RU2481331C2 |
METHODS FOR PREPARING DERIVATIVES OF 1-[2-(BENZIMIDAZOL-1-YL)QUINOLIN-8-YL]PIPERIDIN-4-YLAMINE |
2004 |
- Tom Norma Zhaklin
- Ripin Dejvid Kharold Braun
- Kastal'Di Majkl Dzhejms
|
RU2323214C2 |
BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETILASE INHIBITORS |
2006 |
- Ehndr'Jus Dejvid Majkl
- Stouks Ehlejn Sofi Ehlizabet
- Terner Ehndr'Ju
- Uoring Majkl Dzhejms
|
RU2448965C2 |
QUINAZOLINE DERIVATIVES AS INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) |
2000 |
- Ehnneken Loran Fransua Andre
- Stouks Ehlajn Sofi Ehlizabet
- Tomas Ehndrju Piter
|
RU2291868C2 |
METHOD FOR PREPARING DERIVATIVES OF PHENYLACETIC ACID |
2000 |
- Adzhemoglu Murat
- All'Mendinger Tomas
- Kalinni Dzhon Vinsent
- Serkju Zhak
- Luaseler Oliv'E
- Zedel'Majer Gottfrid
- Sjuj Dejvid
|
RU2273628C2 |
METHOD OF PRODUCING ANDROGEN RECEPTOR ANTAGONISTS AND THEIR INTERMEDIATE COMPOUNDS |
2016 |
- Karjalainen, Oskari
- Laitinen, Ilpo
|
RU2719590C2 |
METHOD FOR PREPITRING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXY-QUINAZOLINE-6-YLOXY)-PIPERIDIN-1-YL)PROP-2-EN-1-ONE |
2014 |
- Pan Kyk Chan
- Chon Che Khek
- Mun Yun Kho
|
RU2671843C2 |
DERIVATIVES OF QUINAZOLINE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF, METHOD OF ATTAINMENT OF ANTIANGIOGENIC EFFECT AND/OR EFFECT OF BLOOD VESSEL PERMEABILITY REDUCTION IN WARM-BLOODED ANIMAL |
1997 |
- Tomas Ehndrju Piter
- Ehnneken Loran Fransua Andre
- Dzhonstoun Krejg
- Stouks Ehlejn Sofi Ehlizabet
- Loman Zhan-Zhak Marsel'
- Klehjton Ehdvard
|
RU2198879C2 |
METHOD OF SYNTHESIS OF R-(+)-1,2,3,6-TETRAHYDRO-4-PHENYL-1- -[(3-PHENYL-3-CYCLOHEXENE-1-YL)METHYL]PYRIDINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS, INTERMEDIATE SUBSTANCES AND METHODS OF THEIR SYNTHESIS |
1995 |
- Donal'D Judzhin Batler
- Dzhodett Dzhejlej
- Tang Van Li
- Viliem Dzhon Iii Smit
- Dejvid Jurgen Vjustro
|
RU2144026C1 |
DERIVATIVES OF QUINAZOLINE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND METHOD OF ACHIEVEMENT OF ANTI-ANGIOGENIC EFFECT AND/OR EFFECT OF DECREASE OF VASCULAR PENETRATION WITH THEIR USING |
1996 |
- Lomann Zhan-Zhak Marsel'
- Ehnneken Loran Fransua Andre
- Tomas Ehndrju Piter
|
RU2194701C2 |