HETEROCYCLIC COMPOUNDS Russian patent published in 2006 - IPC C07D235/06 C07D209/08 C07D403/06 A61K31/445 A61K31/40 A61K31/495 A61P9/00 A61P29/00 

FIELD: organic chemistry of heterocyclic compounds, biochemistry.

SUBSTANCE: invention relates to new ortho-substituted and N-substituted indoles of the formula (α): or (β): or their pharmaceutically acceptable salts wherein Z¹ represents -CR⁴ or nitrogen atom (N); R⁴ means hydrogen atom (H), (C₁-C₆)-alkyl comprising optionally oxygen atom (O) or nitrogen atom (N) possibly substituted with halogen atom, keto-group, 5-6-membered cycloaliphatic radical possibly comprising 1-2 oxygen atoms (O) or nitrogen atom (N); Z² represents -CH or -CR wherein R means (C₁-C₆)-alkyl; R¹ means compound of the formula: wherein X¹ means -CO or its isostere; m = 0, 1; Y represents alkyl that can be substituted; or two Y form in common (C₂-C₃)-alkylene; n = 0, 1 or 2; Z³ represents -CH; X² represents -CH, -CH₂ or their isostere; Ar represents one or two phenyl groups bound with X² wherein phenyl can be substituted; R² represents hydrogen atom (H), (C₁-C₆)-alkyl or aryl wherein each aryl comprises, possibly, oxygen atom (O) or nitrogen atom (N) and can be substituted. Proposed compounds are selective inhibitors of p38α kinase.

EFFECT: valuable biochemical properties of compounds.

34 cl, 5 tbl, 23 ex