HYPERTHERMIC INTRAOPERATIVE INTRAPERITONEAL CHEMOTHERAPY METHOD FOR TREATING THE CASES OF GENERALIZED MALIGNANT OVARIAN NEOPLASMS Russian patent published in 2006 - IPC A61K31/282 A61K31/407 A61K31/513 A61P35/00 A61B17/00 

Abstract RU 2271206 C1

FIELD: medicine.

SUBSTANCE: method involves carrying out radical surgical intervention. Abdominal cavity lavage is carried out using lavage solutions during 15-20 min after having accomplished all surgical intervention stages. The lavage solution is removed from abdominal cavity. Draining silicon tubes are set into the right subdiaphragmal space, into the right subhepatic space and into the right lateral canal, into the left subdiaphragmal space, into the right lateral canal and into small pelvis. Abdominal reservoir is formed by suspending laparotomic wound edges by means of Seagal retractor. Polyethylene film having cruciform cut in its center is fixed on laparotomic wound edges. The abdominal reservoir is filled with isotonic solution on sodium chloride bases or on dialysis solution base or on Ringer-Lock solution base as perfusate. The solution contains primary and additional chemopreparations. Perfusion solution has Cysplatin or Platinol or Carboplatin at a dose of 50 mg/m2 of patient skin area or Mytomicin C at a dose of 20 mg/m2 of patient skin area as the primary preparation and 5-Fluorouracyl as the additional preparation at a dose of 1 mg/m2 of patient skin area. The perfusion solution is introduced via draining tubes at 44-46°C into upper regions of the abdominal cavity. The solution is evacuated from it at a temperature not lower than 42.5°C via draining tubes arranged in pelvic cavity and iliac regions. Perfusion solution chemopreparations temperature control is carried out by means of heat sensor transducers mounted in draining tubes. Chemotherapy is carried out with closed perfusion solution chemopreparations circulation during 60-120 min in abdominal cavity at a rate of 500-2000 ml/min concurrently manually mixing the chemopreparation solution. The abdominal cavity is tightly sutured after having applied the hyperthermic intraoperative intraperitoneal chemotherapy. Intraperitoneal chemotherapy is carried out in postoperative period daily from the first to the fifth day after the operation. To do it, chemotherapeutic solution based on physiologic sodium chloride solution or on dialysis solution or on Ringer-Lock solution, containing 5-Fluorouracyl at a dose of 1 mg/m2 of patient skin area is introduced via retained draining tubes with its exposure time being equal to 8-12 h. Then the draining tubes are removed.

EFFECT: enhanced effectiveness of treatment; prevented abdominal cavity and small pelvis region from being inseminated; prolonged survival period; improved life quality.

9 cl

Similar patents RU2271206C1

Title Year Author Number
HYPERTHERMIC INTRAOPERATIVE INTRAPERITONEAL CHEMOTHERAPY METHOD FOR TREATING THE CASES OF GENERALIZED MALIGNANT COLON NEOPLASMS 2004
  • Nemytin Jurij Viktorovich
  • Kitaev Aleksandr Vasil'Evich
  • Leonov Sergej Vital'Evich
  • Varnachev Aleksej Pavlovich
RU2271207C1
HYPERTHERMIC INTRAOPERATIVE INTRAPERITONEAL CHEMOTHERAPY METHOD FOR TREATING THE CASES OF GENERALIZED MALIGNANT RECTAL NEOPLASMS 2004
  • Nemytin Jurij Viktorovich
  • Kitaev Aleksandr Vasil'Evich
  • Leonov Sergej Vital'Evich
  • Varnachev Aleksej Pavlovich
RU2271204C1
HYPERTHERMIC INTRAOPERATIVE INTRAPERITONEAL CHEMOTHERAPY METHOD FOR TREATING THE CASES OF GENERALIZED MALIGNANT STOMACH NEOPLASMS 2004
  • Nemytin Jurij Viktorovich
  • Kitaev Aleksandr Vasil'Evich
  • Leonov Sergej Vital'Evich
  • Varnachev Aleksej Pavlovich
RU2271205C1
METHOD OF INTRAOPERATIVE INTRACAVITY HYPERTHERMIC CHEMOTHERAPY IN DISSEMINATED ABDOMINAL AND PELVIC CANCER IN HUMAN 2008
  • Kitaev Aleksandr Vasil'Evich
  • Petrov Valentin Pavlovich
  • Azbarov Anatolij Akimovich
  • Bykhovets Igor' Vasil'Evich
  • Pavlov Artem Viktorovich
  • Abdulaev Khalil Rashidovich
  • Muslimov Muslim Ildrym Ogly
  • Ljutskij Vladimir Igorevich
  • Romanovskaja Svetlana Viktorovna
RU2406451C2
METHOD OF CARCINOMATOUS ASCITES SURGICAL TREATMENT ASSOCIATED WITH TUMOR PROCESS DISSEMINATION ALONG PARIETAL AND VISCERAL PERITONEUM 2006
  • Kitaev Aleksandr Vasil'Evich
  • Petrov Valentin Pavlovich
  • Stoljarzh Aleksej Borisovich
  • Leonov Sergej Vital'Evich
  • Gilevskij Sergej Gennad'Evich
  • Abdulaev Khalil Rashidovich
RU2326603C1
METHOD OF INTREOPERATIVE INTRACAVITARY HYPERTHERMIC CHEMOTHERAPY FOR HUMAN DISSEMINATED MALIGNANT PLEURAL GROWTH 2007
  • Kitaev Aleksandr Vasil'Evich
  • Petrov Valentin Pavlovich
  • Azbarov Anatolij Akimovich
  • Bykhovets Igor' Vasil'Evich
  • Pavlov Artem Viktorovich
  • Abdulaev Khalil Rashidovich
  • Muslimov Muslim Ildrym Ogly
  • Ljutskij Vladimir Igorevich
  • Romanovskaja Svetlana Viktorovna
RU2353307C2
METHOD FOR APPLYING ANESTHESIA WHEN PERFORMING HYPERTHERMIC INTRAOPERATIVE CHEMOTHERAPY OF MALIGNANT NEOPLASMS IN ABDOMINAL CAVITY AND SMALL PELVIS ORGANS 2006
  • Azbarov Anatolij Akimovich
  • Kiselev Dmitrij Ivanovich
  • Kitaev Aleksandr Vasil'Evich
  • Pavlov Artem Viktorovich
  • Rogovoj Konstantin Vladimirovich
RU2307649C1
METHOD OF SINGLE-STAGE INSTALLATION OF INTRAPERITONEAL PORT-SYSTEM IN COMBINATION WITH HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC), INCLUDING INTRAOPERATIVE INSTALLATION OF INTRAPERITONEAL PORT-SYSTEM WITH POSSIBILITY OF FURTHER CARRYING OUT OF NORMOTHERMAL CHEMO-PERFUSION THROUGH PORT SYSTEM 2020
  • Taratonov Aleksej Vladimirovich
  • Saevets Valeriya Vladimirovna
  • Privalov Aleksej Valerevich
  • Mukhin Arsentij Andreevich
RU2740628C1
METHOD OF INTRAOPERATIVE PHOTODYNAMIC PERITONEAL THERAPY 2010
  • Chissov Valerij Ivanovich
  • Filonenko Elena Vjacheslavovna
  • Grishin Nikolaj Aleksandrovich
  • Vashakmadze Levan Archilovich
  • Butenko Aleksej Vladimirovich
  • Khomjakov Vladimir Mikhajlovich
  • Lukin Vitalij Vladimirovich
  • Kirillov Nikita Vasil'Evich
  • Sidorov Dmitrij Vladimirovich
  • Lozhkin Mikhail Vladimirovich
  • Petrov Leonid Olegovich
RU2449819C2
METHOD OF CURING MALICIOUS TUMORS BY REGIONAL HYPERTHERMIA OF ABDOMINAL 2005
  • Karpikov Denis Anatol'Evich
  • Karpikova Tat'Jana Mikhajlovna
  • Bazanov Kirill Vladimirovich
RU2288752C2

RU 2 271 206 C1

Authors

Nemytin Jurij Viktorovich

Kitaev Aleksandr Vasil'Evich

Leonov Sergej Vital'Evich

Varnachev Aleksej Pavlovich

Dates

2006-03-10Published

2004-12-02Filed