METHOD FOR DETERMINING UREMIC ENCEPHALOPATHY DEVELOPMENT DEGREE IN PATIENTS SUFFERING FROM CHRONIC RENAL INSUFFICIENCY Russian patent published in 2006 - IPC A61B5/484 A61B5/476 

FIELD: medicine.

SUBSTANCE: method involves carrying out electroencephalography and cognitive evoked potentials examination on showing binaural acoustic stimulation with 50 ms long pulses which intensity is of 80 dB with 2 s long pauses between stimuli, significant tone frequency equal to 2000 Hz, insignificant one equal to 1000 Hz when shown in pseudo random order. Three series of averaging are recorded with significant tone being repeated 26 times in each of them. The testee counts the significant tones in mind within the second and third series. N2, P3 peak latency and P3 peak amplitude are determined in the first (A1) and in the second (A2) averaging series. Habituation is calculated as A2/A1*100 and A coefficient as ratio of habituation P3 peak amplitude and P3 amplitude of the first averaging series. P3 peak latency being increased when compared to normal reference value in combination with dominated slow electroencephalography activity, severe uremic encephalopathy is to be diagnosed. Habituation P3 peak amplitude growing higher than 100%, P3 peak latency being normal and A coefficient not exceeding 12.31% mcV in combination with electroencephalogram beta-rhythm dominated by frequency below 25 Hz spread allover the whole convex with distinct rhythm mastering response to rhythmic photostimulation in broad frequency bandwidth taking place, mild uremic encephalopathy severity degree is to be diagnosed. Coefficient A value exceeding 12.31% mcV, P3 peak latency being normal in combination with high distant oscillation synchronization, low frequency alpha-rhythm being recorded, zonal amplitude differences being smoothed and theta-waves outbursts being available in frontal central leads, moderate uremic encephalopathy severity degree is to be diagnosed.

EFFECT: high diagnosis reliability.

2 cl, 8 tbl