METHOD FOR PREPARING ALKOXYPHENYLACETIC ACID NITRILES (VARIANTS) AND HALOMETHYL DERIVATIVES OF PHENOL ESTERS Russian patent published in 2006 - IPC C07C253/14 

Abstract RU 2273631 C1

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to methods (variants) for preparing alkoxyphenylacetic acid nitriles of the general formula (I): , wherein R1 means (C1-C6)-alkyl, (C1-C6)-alkoxy-group, hydrogen atom; R2 means (C1-C6)-alkyl, (C1-C6)-alkoxy-group, hydrogen atom; R3 means (C1-C6)-alkyl. Also, invention relates to a method for preparing intermediate halomethyl derivatives of phenol esters of the general formula (II): , wherein R1, R2 and R3 have abovementioned values and Gal means halogen atom that are known as intermediate compounds used in synthesis of medicinal preparations. Method for preparing nitriles involves the halomethylation reaction of phenol esters with formaldehyde and a mixture of hydrogen halide acid and haloanhydride in their ratio = 1:(0.15-0.35) in the presence of inert solvent followed by the cyaniding reaction of halomethyl derivatives formed. Method allows isolation of intermediate halomethyl derivatives of phenol esters.

EFFECT: improved preparing method.

6 cl, 5 ex

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RU 2 273 631 C1

Authors

Pyshchev Aleksandr Ivanovich

Dates

2006-04-10Published

2004-11-15Filed