FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to methods (variants) for preparing alkoxyphenylacetic acid nitriles of the general formula (I): , wherein R1 means (C1-C6)-alkyl, (C1-C6)-alkoxy-group, hydrogen atom; R2 means (C1-C6)-alkyl, (C1-C6)-alkoxy-group, hydrogen atom; R3 means (C1-C6)-alkyl. Also, invention relates to a method for preparing intermediate halomethyl derivatives of phenol esters of the general formula (II): , wherein R1, R2 and R3 have abovementioned values and Gal means halogen atom that are known as intermediate compounds used in synthesis of medicinal preparations. Method for preparing nitriles involves the halomethylation reaction of phenol esters with formaldehyde and a mixture of hydrogen halide acid and haloanhydride in their ratio = 1:(0.15-0.35) in the presence of inert solvent followed by the cyaniding reaction of halomethyl derivatives formed. Method allows isolation of intermediate halomethyl derivatives of phenol esters.
EFFECT: improved preparing method.
6 cl, 5 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF SYNTHESIS OF ALKOXYPHENYLACETIC ACID NITRILES (VARIANTS) | 1997 |
|
RU2133736C1 |
2-METHYL-2-(3-PHENOXYBENZOATE)PROPANENITRILE SYNTHESIS METHOD | 2009 |
|
RU2398762C1 |
HALIDES OF HALOGENSULFONYBENZOIC ACID, METHOD OF OBTAINING IT AND ITS USE FOR OBTAINING THE SUBSTITUTED PHENYLSULFONYLUREAS | 2003 |
|
RU2330027C2 |
HYDROQUINONE DERIVATIVES AS FREE OR SALT, METHODS OF THEIR SYNTHESIS, PIPERIDINE DERIVATIVES AND METHODS OF THEIR SYNTHESIS | 1992 |
|
RU2095339C1 |
BIPHENYLPYRIDONE DERIVATIVES AND THEIR SALTS | 1992 |
|
RU2100350C1 |
CHLOROPYRIDINIUM CHLORIDES AND METHOD OF PREPARATION THEREOF | 1995 |
|
RU2138481C1 |
DERIVATIVES OF PHENOL AND COMPOSITION USED FOR INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS GROWTH AND REPLICATION BASED ON THEREOF | 1990 |
|
RU2108785C1 |
METHOD FOR PREPARING DERIVATIVES OF 1-PHENYLPYRAZOLINE-3-CARBOXYLIC ACID | 1998 |
|
RU2232754C2 |
AMIDINE DERIVATIVES, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND SALTS, PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC EFFECT WITH RESPECT TO LEUKOTRIENE-B | 1993 |
|
RU2124002C1 |
POLYESTER, METHOD OF IMPARTING WHITENESS TO POLYESTERS, TONIC COMPOSITION OF PREMIX, MOLDED PRODUCT | 1994 |
|
RU2142477C1 |
Authors
Dates
2006-04-10—Published
2004-11-15—Filed