FIELD: organic chemistry. SUBSTANCE: products: derivatives of biphenylpyridone of the formula (I) $$$ where $$$ - $$$-alkyl, $$$-cycloalkyl, halogen; A - direct bond, oxygen or sulfur atom, group $$$ or $$$; $$$ - H, $$$-alkyl; $$$ - H, halogen, $$$-alkyl, formyl, $$$; $$$ - H, $$$-alkyl, alkaline metal; $$$ - H, $$$-alkyl, phenyl, cyano-group, group $$$, group C(O)-$$$; $$$ and $$$ - hydrogen, $$$-alkyl, $$$-cycloalkyl, benzyl; $$$ - hydrogen, cyano-group, halogen, $$$-alkyl, $$$-alkenyl, $$$; $$$ - H; D - residue of the formula (II) $$$ where $$$ - $$$ where $$$ - H, $$$-alkyl, CO-NH-$$$. Reagent 1: pyridone of the formula (III) $$$ where $$$ and A - as indicated above. Reagent 2: compound of the formula (IV) $$$ where E - halogen; L - residue of the formula (V) $$$ where $$$ - alkoxycarbonyl-$$$. Reaction conditions: in medium of inert solvent, in the presence of base. The synthesized compounds were used in medicine as antagonists of angiotensin-II. EFFECT: improved method of synthesis. 3 cl
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