FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 2-methyl-2-(3-phenoxybenzoate)-propanenitrile of formula , which can be used in organic synthesis, including production of biologically active substances. The method involves reaction of acid chloride of 3-phenoxybenzoic acid with acetone cyanohydrin in a medium of absolute diethyl ether and in the presence of triethylamine as a hydrogen chloride acceptor. The process is carried out in molar ratio of acid chloride of 3-phenoxybenzoic acid : acetone cyanohydrin : triethylamine equal to 1 : 1.2 : 1.2 respectively for 1 hour at 30-36 °C.
EFFECT: method enables to obtain 2-methyl-2-(3-phenoxybenzoate)propanenitrile with good output and high degree of purity.
2 cl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PRODUCING 2-(3-PHENOXY PHENYL-SUBSTITUTED)BENZOXAZOLES | 2011 |
|
RU2473546C2 |
METHOD OF PRODUCING 1-(3-PHENOXYPHENYL)BUTANE-1,3-DIONE | 2013 |
|
RU2529029C1 |
METHOD OF PRODUCING 2-(3-PHENOXYPHENYL-SUBSTITUTED)BENZIMIDAZOLES | 2011 |
|
RU2453539C1 |
METHOD OF PRODUCING N'-BENZOYL-N-SUBSTITUTED AMIDINES OF 3-PHENOXY BENZOIC ACID OR DERIVATIVES THEREOF | 2009 |
|
RU2408575C1 |
METHOD OF PRODUCING 6-(3-PHENOXYPHENYL-SUBSTITUTED) 2,4-DIAMINO-SIMM-TRIAZINES | 2011 |
|
RU2451678C1 |
3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES AS STARTING COMPOUNDS FOR PRODUCING CHELATE COMPLEXES THEREOF WITH COPPER (II) IONS AND METHOD OF PRODUCING 3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES | 2012 |
|
RU2475473C1 |
METHOD OF PRODUCING ETHYL 5-METHYL-3-(3-PHENOXYPHENYL)-1-PHENYL-1H-PYRAZOLYL-4-CARBOXYLATE | 2015 |
|
RU2582127C1 |
METHOD OF PRODUCING ETHYL 5-METHYL-3-(3-PHENOXYPHENYL)ISOXAZOLE-4-CARBOXYLATE | 2015 |
|
RU2592281C1 |
METHOD OF PRODUCING ADAMANTYL ESTERS OF UNSATURATED ACIDS | 2010 |
|
RU2448950C1 |
METHOD OF PRODUCING 1-(2-METHYL-1,4-PHENOXYPHENYL)-BUTANE-1,3-DIONE | 2012 |
|
RU2478606C1 |
Authors
Dates
2010-09-10—Published
2009-03-10—Filed