METHOD FOR REMOVING INTRAOCULAR NEOPLASMS Russian patent published in 2006 - IPC A61F9/08 A61N5/67 A61K31/409 

FIELD: medicine.

SUBSTANCE: method involves carrying out vitrectomy, retinotomy and exposing the intraocular neoplasm. Liquid-to-gas exchange is carried out. Chlorine row photosensibilizer is intrastromally introduced into the tumor in 0.35-0.5% solution in the amount of 0.1-0.5 ml. Chlorine row photosensibilizer is intravitreally applied to the tumor in 1.0-2.0% gel in the amount of 0.2-0.3 ml. Fluorescent spectral diagnostic examination of the neoplasm is carried out after having kept far from light for 20-30 min. When observing fluorescence, the neoplasm is intravitreally exposed to laser radiation at wavelength corresponding to maximum light radiation absorption by the photosensibilizer with energy density being equal to 100-120 J/cm². Irradiation proceeds field-by-field in circle moving from periphery to the center with neighboring fields overlap equal to 5% of area. The intraocular formation is removed, retina is smoothed by applying perfluororganic substance and delimiting endolaser coagulation of retinotomy zone is carried out. Chlorine row photosensibilizer is intravenously introduced at a dose of 0.8-1.1 mg/kg within 10 min in 10-14 days. 15-20 min long pause is held and fluorescent spectral diagnostic examination of the neoplasm removal zone is carried out. Detected fluorescent zones are to be intravitreally treated with laser radiation at wavelength corresponding to maximum light radiation absorption by the photosensibilizer with energy density being equal to 80-100 J/cm². Then, the perfluororganic substance is substituted for silicon oil. The method is aimed at complete melanoma removal.

EFFECT: reduced risk of viable tumor cells being retained in operation field; excluded intraoperative hemorrhages; reduced risk of neoplasm and metastases formation.

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