PHOTODYNAMIC METHOD FOR TREATING THE CASES OF INTRAOCULAR NEOPLASMS AGGRAVATED WITH SECONDARY RETINA DETACHMENT Russian patent published in 2006 - IPC A61F9/08 A61N5/67 A61K31/409 

FIELD: medicine.

SUBSTANCE: method involves carrying out vitrectomy and removing posterior hyaloid membrane. Perfluororganic substance is introduced into the vitreal cavity. Subretinal fluid is drained. Neoplasm is intravitreally irradiated with low intensity laser radiation having wavelength of 633 nm at a dose of 2.5 J and at wavelength of 890 nm at a dose of 1.2 J in field-by-field mode circularly moving from the center to periphery. Chlorine row photosensibilizer is intravenously introduced at a dose of 0.8-1.1 mg/kg within 10 min. Fluorescent spectral diagnostic examination of the neoplasm is carried out 15-20 min later. When detecting neoplasm fluorescence, it is to be intravitreally irradiated in perfluororganic medium at wavelength equal to maximum light radiation absorbable by the photosensibilizer and power density of 100-120 J/cm². Laser radiation is applied field-by-field mode moving in circles from periphery to the center with neighboring fields overlap equal to 5% of area. Neoplasm destruction products are transretinally drained and retinal laser coagulation is carried out around the neoplasm zone and retinotomy zone. Intravenous photosensibilizer introduction and fluorescent spectral diagnostic examination are repeated in 7-14 days later. When detecting fluorescence zones, they are to be intravitreally irradiated in perfluororganic medium at wavelength equal to maximum light radiation absorbable by the photosensibilizer with power density equal to 80-100 J/cm². Then, the perfluororganic substance is substituted for silicon oil.

EFFECT: enhanced effectiveness of treatment; reduced risk of tumor recurrence, metastases and viable tumor cells being retained; improved anatomical retina adjacency.

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