FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to derivatives of allylamines, namely, to a method for preparing terbinafine or its hydrochloride. Method involves interaction of N-methyl-naphth-1-yl-methylamine taken in excess with 1-halogen-6,6-dimethylheptene-2-ene-4-ine in water or inorganic base an aqueous solution followed by, if necessary, treatment of prepared product with hydrochloric acid. As a rule, as the parent reagent both 1-bromo-6,6-dimethylhept-2-ene-4-ine and 1-chloro-6,6-dimethylhept-2-ene-4-ine is used. Usually 5-50% mole excess of N-methyl-naphth-1-yl-methylamine is used in case using inorganic base. Method provides enhancing yield of the end compound, to simplify the process and to expand the raw base by using the more low-priced 1-chloro-6,6-dimethylhept-2-ene-4-ine as an alkylating agent.
EFFECT: improved preparing method.
3 cl, 3 ex
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