PYRIDYL-SUBSTITUTED HETEROCYCLES, SUITABLE FOR TREATMENT OR PREVENTION OF INFECTIONS, CAUSED BY HEPATITIS C VIRUS Russian patent published in 2008 - IPC C07D401/14 C07D401/04 C07D413/04 C07D413/14 C07D417/04 C07D417/14 A61K31/443 A61K31/4436 A61K31/4439 A61P31/12 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: invention pertains to compounds with formula (I), their pharmaceutical salts or N-oxide used as an inhibitor to replication and/or proliferation of HCV, to the method of inhibiting replication or proliferation of hepatitis C virion using formula (I) compounds, as well as to pharmaceutical compositions based on them. The compounds can be used for treating or preventing infections, caused by hepatitis C virus. In general formula (I) cycle B is an aromatic or non-aromatic ring, which contains two heteroatoms, where X and Y, each is independently chosen from C, CH, N or O, under the condition that, both X and Y are not O and that, both X and Y are not N; U and T represent C; Z represents -CH-; A represents N or -CR²-; B represents -CR³-; D represents N or -CR⁴-; E represents N or -CR⁵-; G represents N or -CR⁶-; J represents N or -CR¹⁴-; K represents -CR⁸-; L represents N or -CR⁹-; M represents N or -CR¹⁰-; R² and R⁶, each is independently chosen from a group, consisting of hydrogen, halogen, C₁-C₆alkyl, substituted C₁-C₆alkyl, C₁-C₆alkoxy, C₁-C₆substituted alkoxy, C₁-C₆alkoxycarbonyl, cycloheteroalkyl, substituted cycloheteroalkyl, -O-carbamoil, substituted -O-carbamoil, halogen C₁-C₆alkyl, diC₁-C₆alkylamino, substituted diC₁-C₆alkylamino and sylye ethers, where cycloheteroalkyl is a 3-7-member ring, containing 1-2 heteroatoms, chosen from N and O, under the condition that, one of R² and R⁶ is not hydrogen; R³ and R⁵, each is independently chosen from a group, consisting of hydrogen, halogen; R⁴ represents hydrogen; R⁷ represents - NR¹¹C(O)R¹²; R⁸, R⁹, R¹⁰ and R¹⁴, each is independently represents hydrogen; R¹¹ represents hydrogen, C₁-C₆alkyl; and R¹² is chosen from a group, consisting of halogen C₁-C₆alkyl; where each substituted group is substituted with one or more groups, chosen from -Q, -R⁴⁰, -OR⁴⁰, -C(O)R⁴⁰, -C(O)OR⁴⁰, where each Q independently represents halogen, R⁴⁰ and R⁴¹ are independently chosen from a group consisting of hydrogen, C₁-C₆alkyl, C₁-C₆alkoxy, under the condition that: (i) at least one of A, D, E, G, J, L or M represents N; (ii) not more than one of A, D, E or G represents N; and (iii) not more than one of J, L or M represents N.

EFFECT: obtaining pyridyl-substituted heterocycles for treating and preventing infections, caused by hepatitis C virus.

33 cl, 85 dwg, 101 ex