MODULATORS OF SODIUM CHANNELS REPRESENTING DERIVATIVES OF 2-PIPERIDYLIMIDAZOLES Russian patent published in 2006 - IPC C07D401/04 C07D233/00 C07D211/00 A61K31/445 A61K31/415

Abstract RU 2275369 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes using compound of the general formula (I): wherein R¹ means hydrogen atom or radical -X-Y-R⁴ wherein -X-Y- means a bond, radical -CO-O-, -CO-NH- or -CS-NH-; R⁴ means alkyl, cycloalkyl or aralkyl; R² means aryl possibly substituted 4 times with halogen atom, alkyl, alkoxyl or aryl; R³ means hydrogen atom, or a pharmaceutically acceptable salt for preparing a medicinal agent designated for effect as a modulator of sodium channels. Also, invention describes a medicinal agent and pharmaceutical composition comprising compound of the formula (I)_M given in the invention description as an active component. Modulators of sodium channels are used in therapy for withdrawal or prophylaxis of pain, migraine, post-operative pains, in epilepsy treatment and in other cases.

EFFECT: valuable medicinal properties of compounds.

13 cl, 26 ex

Similar patents RU2275369C2

Title	Year	Author	Number
DERIVATIVES OF FIVE-MEMBER HETEROCYCLES, METHOD OF PRODUCTION AND USE THEREOF AS MEDICINAL AGENTS	2000	Shabrie De Lasson'Er P'Er-Eht'Enn Kharnett Dzheremia Bigg Denni Pomm'E Zhak Lannua Zhak Liberator Ann-Mari Tjur'O Kristof	RU2380362C2
FIVE-MEROUS HETEROCYCLE DERIVATIVES, METHOD FOR PREPARING AND USING THEM AS THERAPEUTIC AGENTS	2009	Shabrie De Lasson'Er P'Er-Eht'Enn Kharnett Dzheremia Bigg Denni Pomm'E Zhak Lannua Zhak Liberator Ann-Mari Tjur'O Kristof	RU2530882C2
DERIVATIVES OF FIVE-MEMBERED HETEROCYCLES, METHOD FOR THEIR PREPARING AND THEIR USING AS MEDICINES	2000	Shabrie De Lasson'Er P'Er-Eht'Enn Kharnett Dzheremia Bigg Denni Pomm'E Zhak Lannua Zhak Liberator Ann-Mari Tjur'O Kristof	RU2271355C2
DERIVATIVES OF FIVE-MEMBERED HETEROCYCLES, THEIR PREPARING AND USING AS MEDICINAL AGENTS	2002	Kharnett Dzheremia Bigg Denni Liberator Ann-Mari Rollan Alen	RU2288224C2
PRODUCT COMPRISING AT LEAST ONE SUBSTANCE INHIBITING ACTIVITY OF NO-SYNTHASE IN COMBINATION WITH AT LEAST ONE SUBSTANCE INHIBITING ACTIVITY OF PHOSPHOLIPASE A	2000	Oge Mishel' Shabrie De Lasson'Er P'Er-Eht'Enn	RU2256465C2
PHOSPHATASE INHIBITORS cdc25	2001	Prevo Greguar Brezak Pannet'E Mari-Kristin Gal'Sera Kontur Mari-Odil' Tjur'O Kristof Gubehn-Grammatika Fransuaz Djukommen Bernar Lanko Kristof	RU2285521C2
DERIVATIVES OF IMIDAZOLE MODULATING SODIUM CHANNEL	2002	Bigg Denni Pomm'E Zhak Liberator Ann-Mari	RU2296565C2
DERIVATIVES OF BENZOTIAZOLE-4,7-DION AND BENZOXAZOLE-4,7-DION, PRODUCTION AND THERAPEUTIC APPLICATION	2002	Gal'Sera Kontur Mari-Odil' Lavern' Oliv'E Brezak Pannet'E Mari-Kristin Prevo Greguar	RU2326664C2
NOVEL DERIVATIVES OF ARYLIMIDAZOLE, THEIR PREPARATIONS AND THEIR THERAPEUTIC USES	2003	Bigg Denni Liberator Ann-Mari Shabri De Lasson'Er P'Er-Eht'Enn	RU2323216C2
NOVEL DERIVATIVES OF BENZIMIDAZOLE AND THEIR USING AS MEDICAMENTS	2002	Puatu Lidi Bro Valeri Ferrandi Ehrik Tjur'O Kristof	RU2294326C2

RU 2 275 369 C2

Authors

Bigg Denni

Pomm'E Zhak

Liberator Ann-Mari

Dates

2006-04-27—Published

2001-12-27—Filed