ARYL-SUBSTITUTED PYRAZOLES OR TRIAZOLES, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT, METHOD FOR REDUCING INTENSITY OR PROPHYLAXIS Russian patent published in 2006 - IPC C07D231/00 C07D231/10 A61K31/4196 A61K31/415 A61P25/08 

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to aryl-substituted pyrazoles or triazoles of the general formula (I): and their pharmaceutically acceptable salts, prodrugs or solvates wherein X means oxygen (O) or sulfur atom (S); Het means one of group of the formula wherein R₁ means hydrogen atom (H), (C₁-C₆)-alkyl, aminocarbonyl, -C(O)R₁₀; R₂ and R₃ mean independently hydrogen atom (H) or aminocarbonyl; R₅, R₆, R₇ and R₈ mean independently hydrogen (H), halogen atom, (C₁-C₆)-alkyl, -NO₂; R₁₀ means -OR₁₁ wherein R₁₁ means hydrogen atom (H), (C₁-C₆)-alkyl. Compounds of the formula (I) are useful for treatment of neuronal damages observing as result of total or focus ischemia, for treatment or prophylaxis of neurodegenerative states, such as amyotrophic lateral sclerosis and for treatment, prophylaxis or reducing intensity of acute or chronic pains, as agents against entotic sound, anticonvulsant agents, and as anti-maniacal depressants, topical analgesic agents, anti-arrhythmic agents and for treatment or prophylaxis of diabetic neuropathy.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

13 cl, 1 dwg