FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, wherein R1 represents a substituent selected from the group consisting of phenyl, pyridyl, triazolopyridine, pyrazolopyridine and imidazopyridine, where phenyl and pyridyl substituted with one to three R5; each of R2 and R3 are independently selected from the group consisting of hydrogen, (C1-C6) alkyl and (C3-C8) cycloalkyl; or R2 and R3 together with the nitrogen atom to which they are attached, form azetidinyl, pyrrolidinyl or piperidinyl; R4, when present, in each case is halogen or (C1-C6) alkyl; R5 when present is in each case independently selected from a group consisting of halogen, cyano, optionally substituted (C1-C6) alkyl, optionally substituted (C1-C6) alkylthio and optionally substituted (C1-C6) alkoxy, where (C1-C6) alkyl, (C1-C6) alkylthio, (C1-C6) alkoxy optionally substituted with one to three halogen atoms; and a is an integer selected from 0, 1 or 2. Invention also relates to a pharmaceutical composition for inhibiting PDE4 isozymes containing these compounds, and a method of treating using said compounds.
EFFECT: technical result is obtaining novel compounds and pharmaceutical compositions based thereon, which can be used in medicine for treating diseases such as schizophrenia, depression, anxiety, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, chronic obstructive pulmonary disease, inflammation, stroke, asthma and allergic rhinitis.
30 cl, 9 tbl, 64 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| CHEMICAL COMPOUNDS AS INTERLEUKIN-1 INHIBITORS | 2018 |
|
RU2792143C2 |
| BICYCLIC KETONES AND METHODS OF THEIR USE | 2018 |
|
RU2797922C2 |
| PYRAZOLAMINOPIRIMIDINE DERIVATIVES AS LEUCINE-REPEATING KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON DISEASE | 2013 |
|
RU2637948C2 |
| BICYCLIC LACTAMS AND METHODS FOR USE THEREOF | 2016 |
|
RU2716136C2 |
| SPIRO CONDENSED PYRROLIDINE DERIVATIVES AS INHIBITORS OF DEUBIQUITINATING ENZYMES (DUB) | 2017 |
|
RU2730552C2 |
| COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | 2019 |
|
RU2795108C2 |
| COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS | 2016 |
|
RU2717238C2 |
| SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | 2019 |
|
RU2820289C2 |
| NOVEL CONDENSED PYRIDINE DERIVATIVES USED AS C-MET TYROSINE KINASE INHIBITORS | 2013 |
|
RU2619130C2 |
| 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOLE-1-ONES (VARIANTS) INHIBITING RELEASE OF INFLAMMATORY CYTOKINES, PHARMACEUTICAL COMPOSITION AND INHIBITION METHOD | 2002 |
|
RU2299885C2 |
