SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS Russian patent published in 2009 - IPC C07D249/10 A61K31/4196 A61P25/00 

FIELD: chemistry.

SUBSTANCE: described are new derivatives of 1,2,4-triazole with general formula or , their pharmaceutically acceptable salts, where R¹ is H, C_1-6alkyl, CONH₂ or COOH; R² is H; R³ is H, halogen or O-C_1-4 perfluoroalkyl; R⁴ is H or halogen; one of the radicals R⁵, R⁶, R⁷ is H; the other is H or halogen, and the third is O-C_1-6 alkyl, halogen, O-C_0-4alkyl C_1-4perfluoroalkyl, O-C_2-6alkenyl, phenyl, possibly substituted with 1 to 3 substitutes, chosen from halogen, CN, CF₃, pyrazole, -OR^a, where R^a is CF₃, NR^aR^b, where R^a and R^b are C_1-4alkyl, a group with formula C(O)-OR^a, where R^a is C_1-4alkyl, or a group with formula - O-C_1-4alkylphenyl, where phenyl can be substituted with 1 to 3 halogens; a pharmaceutical composition containing said compounds.

EFFECT: use of new compounds for treating and preventing chronic and neuropathic pain.

39 cl, 72 ex