FIELD: chemistry.
SUBSTANCE: described are new derivatives of 1,2,4-triazole with general formula or
, their pharmaceutically acceptable salts, where R1 is H, C1-6alkyl, CONH2 or COOH; R2 is H; R3 is H, halogen or O-C1-4 perfluoroalkyl; R4 is H or halogen; one of the radicals R5, R6, R7 is H; the other is H or halogen, and the third is O-C1-6 alkyl, halogen, O-C0-4alkyl C1-4perfluoroalkyl, O-C2-6alkenyl, phenyl, possibly substituted with 1 to 3 substitutes, chosen from halogen, CN, CF3, pyrazole, -ORa, where Ra is CF3, NRaRb, where Ra and Rb are C1-4alkyl, a group with formula C(O)-ORa, where Ra is C1-4alkyl, or a group with formula - O-C1-4alkylphenyl, where phenyl can be substituted with 1 to 3 halogens; a pharmaceutical composition containing said compounds.
EFFECT: use of new compounds for treating and preventing chronic and neuropathic pain.
39 cl, 72 ex
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Authors
Dates
2009-11-10—Published
2004-11-05—Filed