LIGANDS OF MELANOCORTIN RECEPTORS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D403/12 C07D241/08 C07D207/12 C07D401/12 A61K31/40 A61K31/4025 A61K31/4523 A61K31/495 A61K31/496 A61P3/10 A61P7/00 A61P9/00 A61P11/00 A61P15/00 A61P21/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new compounds including all its enantiomeric and diastereomeric forms, and to their pharmaceutically acceptable salts wherein indicated compound corresponds to the formula: wherein A represents a conformationally limited ring system chosen from the group comprising the following formulae: (a) (d) and (e) wherein carbon atoms labeled by asterisks can be in any stereochemical configuration or their mixtures wherein Y has a formula: -(CH₂)_b-R¹⁵ wherein index b = 1-4, and R¹⁵ represents -OH, -NH₂, guanidine-group, and Z has a formula: wherein R represents hydrogen atom; R⁹ represents naphthylmethyl; R¹⁰ represents -C(X)N(R¹⁶)₂ wherein each R¹⁶ represents independently hydrogen atom or (C₁-C₁₀)-alkyl; X represents oxygen atom; or Z represents naphthylmethyl wherein W has a formula: wherein R represents phenyl substituted optionally with halogen atom of OH-group wherein fragment L is chosen from the group comprising: -NH- or -NHC(O)-; B represents hydrogen atom of fragment of the formula: wherein fragments R², R³ and R⁴ are chosen independently among the group comprising hydrogen atom, -NHC(O)CH₃, benzyl substituted optionally with hydroxy-group or halogen atom, imidazolylmethyl; or fragments R², R³ and R represent in common naphthalinyl or isoquinolinyl; or one radical among R², R³ and R⁴ represents hydrogen atom and two radical among R, R³ or R⁴ chosen in common form piperidine ring or tetrahydroisoquinoline ring substituted optionally with the group -C(O)CH₃. Also, invention relates to a pharmaceutical composition possessing the agonistic activity with respect to MC-3/MC-4 receptors based on these compounds. Invention provides preparing new compounds and pharmaceutical compositions based on thereof for aims in treatment of disorders mediated by function of MC-3/MC-4 receptors.

EFFECT: valuable medicinal properties of compounds and compositions.

17 cl, 14 tbl, 12 ex