QUINOXALINES AND AZAQUINOXALINES AS CRTH RECEPTOR MODULATORS Russian patent published in 2016 - IPC C07D241/36 C07D401/06 C07D401/12 C07D403/06 C07D403/12 C07D403/14 C07D471/04 A61K31/498 A61K31/4985 A61P11/02 A61P11/06 

FIELD: chemistry.

SUBSTANCE: invention relates to compound of formula (IC) and pharmaceutically acceptable salts thereof. Disclosed compounds have properties of CRTH₂ receptor modulators. In formula (IC)

R¹ represents -C(O)-N(R^6a)(R^6b); I) R^6a is H, and R^6b represents a) -Q-R^AH, where R^AH is phenyl, and where R^AH is unsubstituted or substituted with one fragment R⁸, selected from group consisting of fluorine and -CN; Q is selected from group consisting of (i) link;

(ii) ,

where R^e denotes H, and R^(f) is H or methyl; b) -Q-R^HC, where R^HC is C₅-C₆ cycloalkyl, where said C₅-C₆ cycloalkyl forms condensed cycle with benzene ring and where R^HC is unsubstituted or substituted with 1-2 fragments of R¹², independently selected from group consisting of halogen and -CN; II) or R^6a and R^6b together with N atom to which they are bonded form R^6h, where R^6h is pyrrolidinyl, piperidinyl or piperazinyl, where R^6h is substituted with -Z-R^CY, Z is bond and R^CY is unsubstituted phenyl or phenyl, substituted with 1-2 fragments of R¹⁰, selected from group consisting of halogen and -CN; R^6H optionally substituted with 1-2 fragments in R⁹, where each fragment R⁹ is independently C₁-C₃ alkyl, halogen or -CN, and R² is unsubstituted phenyl. Invention also relates to pharmaceutical composition for treating asthma or allergic rhinitis and method of treating asthma or allergic rhinitis.

EFFECT: technical result is obtaining novel compounds which can be used to treat asthma or allergic rhinitis.

10 cl, 2 tbl, 44 ex