ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYLOXAZOLIDINONES Russian patent published in 2006 - IPC C07D413/10 C07D471/04 C07D487/04 A61K31/422 A61P31/04 

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to bicyclic heterocyclic substituted phenyloxazolidinones that represent compounds of the formula (I): wherein R is taken from the group consisting of -OH, O-heteroaryl, -N₃, -OSO₂R'', -NR'''R'''', or the formula: wherein: (ii) R'' represents direct or branched alkyl comprising up to 5 carbon atoms; (iii) R''' and R'''' are taken independently from the group consisting of hydrogen atom (H), -CO₂-R₁, -CO-R₁, -CS-R₁ and -SO₂-R₄ wherein R₁ is taken among the group consisting of cycloalkyl comprising from 3 to 6 carbon atoms and direct or branched alkyl comprising up to 6 carbon atoms; R₄ is taken from direct or branched alkyl comprising up to 4 carbon atoms; and R_4a represents -CN or -NO₂; R_4b represents -SR_4c, amino-group, -NHR_4c or -NR_4cR_4d wherein R_4c and R_4d are taken independently from hydrogen atom (H) or alkyl; X represents from 0 to 4 members taken independently from the group consisting of halogen atom; and Y represents radical of the formula (II): or (III): wherein R₅, R₆, R₇ and R₈ represent independently hydrogen atom (H), or R and R₆ and/or R₇ and R₈ form in common oxo-group; R₉ and R₁₀ represent independently hydrogen atom (H); A, B, C and D are taken from carbon atom (C) and nitrogen atom (N) to form phenyl ring or 5-6-membered heteroaromatic ring wherein the indicated heteroaromatic ring comprises from 1 to 4 members taken from the group consisting of nitrogen atom (N); Z is taken from alkyl, heteroaryl comprising nitrogen atom (N); and m represents 0 or 1. These compounds are useful as antibacterial agents and can be used for treatment of patient with the state caused the bacterial infection or with the bacterial infection caused by S. aureus and E. faecium.

EFFECT: valuable medicinal properties of compounds.

45 cl, 1 tbl, 50 ex