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(19)

RU

(11)

2 278 121

(13)

C2

(51)

IPC

C07D493/18(2006-01-01)

C07D493/22(2006-01-01)

A61K31/343(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2003124760/04, 2002-01-11

(24)

Start date

2002-01-11

(22)

Actual filing date

2002-01-11

(45)

Published

2006-06-20

(72)

Inventor

Lavern' Oliv'ELanko KristofPrevo GreguarTeng Beng Poon

(73)

Holder

Sos'Ete De Konsej De Reshersh Eh D`Applikas'On S'Entifik

DERIVATIVES OF MYCANOLIDE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND THEIR USING Russian patent published in 2006 - IPC C07D493/18 C07D493/22 A61K31/343 A61P35/00 

Abstract RU 2278121 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of mycanolide of the formula (I): corresponding to the general subformulae (I)1 and (I)2 wherein L, R1 and R2 have values given in the invention description. Also, invention relates to a medicinal agent and pharmaceutical composition based on compounds of the formula (I), and to using compounds of the formula (I) for preparing a medicinal agent designated for inhibition of activity of DNA polymerases and treatment of diseases arising as result of anomalous cellular proliferation. Invention provides preparing new derivatives of mycanolide possessing the valuable pharmaceutical effect.

EFFECT: valuable medicinal and biochemical properties of derivatives.

12 cl, 2 tbl, 52 ex

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RU 2 278 121 C2

Authors

Lavern' Oliv'E

Lanko Kristof

Prevo Greguar

Teng Beng Poon

Dates

2006-06-20—Published

2002-01-11—Filed

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