DIAZABICYCLOALKENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of diazabicycloalkenes of the formula (I) where R¹ means a group of the formula (II) or (III) ; R¹¹ and R¹² - lower alkyl or taken together they form lower alkylene group; R¹³ - hydroxyl, lower acyloxy-group; R¹⁴ - hydrogen atom or lower alkyl; A - nitrogen atom or C-R¹⁶ where R¹⁶ - hydrogen, cyano-, nitro-, trifluoromethoxy-, penta- -fluoroethyl-, sulfonyl-group possibly substituted with aryl, carbamoylethyl- or sulfamoyl-group; R¹⁵ - hydrogen, nitro-group; R²¹ and R²² - lower alkyl; R²³ - hydroxyl; R²⁴ and R²⁵ - hydrogen; X - oxygen or N-R³¹ where R³¹ - hydrogen; R² - hydrogen alkenyl, alkynyl, alkyl; or R² - optionally substituted alkylphenyl; R³ and R⁴ - hydrogen or alkyl; n = 1, or their pharmaceutically acceptable salts. Compounds of the formula (I) show an excellent activity enhancing potassium exchange by potassium channel opening. EFFECT: enhanced effectiveness of compounds synthesized. 9 cl, 13 tbl, 47 ex