HEMIN-PEPTIDES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION AND USING AS ANTI-TUMOR AGENTS Russian patent published in 2006 - IPC C07K14/805 C07D487/22 A61K38/41 A61P35/00 

Abstract RU 2280649 C1

FIELD: chemistry of natural organic compounds, medicine, oncology, pharmacy.

SUBSTANCE: invention proposes hemin-peptides of the general formula (I): wherein R1 and R2 are substitutes that can represent peptide consisting of 1-7 amino acids wherein carboxyl groups of peptide can be modified with (C1-C8)-alkyl ester and by-side groups of amino acids of peptide can be protected and chosen from the group wherein: at R1 means: Arg-Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R2 means -OH at R1 - Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R2 means -OH; at R1 - SerOMe; R2 - SerOMe, at R1 - AspOH; R2 - AspOH; Me represents Fe; Y represents Cl wherein carboxyl group of hemin can be modified with methyl or (C2-C8)-ester or physiologically acceptable salt; or its pharmaceutically acceptable salts. hemin-peptides possess capacity to induce apoptosis of cells and show anti-tumor effect and can be used for biomedicinal aims.

EFFECT: valuable medicinal properties of hemin-peptides.

5 cl, 1 tbl, 9 ex

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RU 2 280 649 C1

Authors

Nebol'Sin Vladimir Evgen'Evich

Zheltukhina Galina Aleksandrovna

Lobanova Tat'Jana Nikolaevna

Dates

2006-07-27Published

2004-11-26Filed