FIELD: chemistry of natural organic compounds, medicine, oncology, pharmacy.
SUBSTANCE: invention proposes hemin-peptides of the general formula (I): wherein R1 and R2 are substitutes that can represent peptide consisting of 1-7 amino acids wherein carboxyl groups of peptide can be modified with (C1-C8)-alkyl ester and by-side groups of amino acids of peptide can be protected and chosen from the group wherein: at R1 means: Arg-Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R2 means -OH at R1 - Trp-His-Arg-Leu-Lys-Glu(OMe)-OH; R2 means -OH; at R1 - SerOMe; R2 - SerOMe, at R1 - AspOH; R2 - AspOH; Me represents Fe; Y represents Cl wherein carboxyl group of hemin can be modified with methyl or (C2-C8)-ester or physiologically acceptable salt; or its pharmaceutically acceptable salts. hemin-peptides possess capacity to induce apoptosis of cells and show anti-tumor effect and can be used for biomedicinal aims.
EFFECT: valuable medicinal properties of hemin-peptides.
5 cl, 1 tbl, 9 ex
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Authors
Dates
2006-07-27—Published
2004-11-26—Filed