METHOD FOR PRODUCTION OF GEMINIPEPTIDES AS NUCLEOTIC AGENTS Russian patent published in 2005 - IPC

Abstract RU 2250906 C2

FIELD: microbiology.

SUBSTANCE: invention relates to method for production of porphyrinopeptides satisfying the formula I , wherein R₁ and R₂ independently from one another represent amino acids or peptides comprising 2-15 of amino acid residues, wherein α-carboxylic groups of amino acids or peptides may be modified by C1-C8-alkyl ester and side functional groups of amino acids or peptides may be protected; in particular R₁ is ArgOMe; R₂ is -OH (III); R₁ is LeuHisOMe; R₂ is -OH (IV); R₁ is LeuLeuValPheOMe; R₂ is -OH (V); porphyrin carboxylic group may be modified by methyl or other C1-C9-ester or pharmaceutically acceptable salt; Y^- represents Cl^-; Me represents Zn, Cu, Fe, Mn. Claimed method includes activation of porphyrin carboxylic group with N-oxy-5-norbornene-2,3-dicarboxyimede in molar ratio of 1:1 in presence of N,N'-dicyclohexylcarbodiinide; or with diphenylphosphorylazide (DPPA) in equimolar ratio of porphyrin/DPPA in presence of base. Then porphyrin with activated carboxylic group is brought into reaction with amino component (amino acid or peptide) in form of mineral acid salt, which is neutralized with base. Also disclosed are methods for application of compounds (I) as nucleotic agents.

EFFECT: new nucleotic agents.

4 cl, 7 ex, 1 tbl

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RU 2 250 906 C2

Authors

Nebol'Sin V.E.

Zheltukhina G.A.

Lobanova T.N.

Dates

2005-04-27—Published

2003-07-10—Filed