AGENT FOR EARLY PATHOGENETIC THERAPY OF ACUTE RADIATION DISEASE Russian patent published in 2006 - IPC A61K31/203 A61K31/355 A61K31/375 A61K31/95 A61P39/00 

FIELD: medicine, medicinal radiobiology, pharmacy.

SUBSTANCE: invention proposes a multicomponent antioxidant complex comprising the following quenching agents of free radicals - ascorbic acid, alpha-tocopherol acetate, retinal acetate, unithiol and sodium selenite as a blocking agent of initiation of free-radical processes. By effect on viability of irradiated animals the invention exceeds the agent-prototype by 2-6 times. In distinction from the prototype, the claimed agent reduces the expression of maximal leukopenia by above two-fold, decreases the concentration of malonic dialdehyde by 1.5-2.0-fold, normalizes the intensity of free-radical oxidation in blood plasma and liver tissue and results to increasing activity of antioxidant systems. Invention can be used in treatment of acute radiation disease.

EFFECT: enhanced and valuable medicinal properties of agent.

6 tbl, 2 ex