FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for synthesis of new compounds, namely, 1,11-dialkyl-3,5-dihydrofuro-[2',3':3,4]-cyclohepta[c]isochromens of the formula: (Ia-f): 
wherein (Ia): R means hydrogen atom (H); R1 means hydrogen atom (H); (Ib): R means bromine atom (Br); R1 means hydrogen atom (H); (Ic): R means chlorine atom (Cl); R1 means hydrogen atom (H); (Id): R means hydrogen atom (H); R1 means bromine atom (Br): (Ie): R means hydrogen atom (H); R1 means chlorine atom (Cl); (If): R means methoxy-group (-OCH3); R1 means hydrogen atom. Method involves formation of condensed tetracyclic system as result of the successive recyclization reactions of furan ring of derivatives of 2-bis-(5-methyl-2-furylmethyl)phenylmethanol and the secondary cyclization of formed isochromen ketone in boiling of solution containing derivatives of 2-bis-(5-methyl-2-furylmethyl)phenylmethanol of the formula: 
in ethanol medium in the presence of hydrogen chloride alcoholic solution for 15-40 min. Invention provides synthesis of new derivatives of isochromens possessing the potential anti-inflammatory activity.
EFFECT: improved method of synthesis, valuable medicinal properties of compounds.
1 cl, 2 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING DERIVATIVES OF 3,5-DIHYDRO-1,11-DIMETHYLFURO[2',3':3,4]CYCLOHEPTA[C]ISOQUINOLINE-5-ONE | 2005 |
|
RU2282632C1 |
| METHOD OF PRODUCING 1,2-DIHYDROPYRROLO[1,2-a]PYRAZIN-3(4H)-ONE DERIVATIVES | 2012 |
|
RU2490271C1 |
| METHOD OF OBTAINING DERIVATIVES OF N-ACETYL-4-HYDROXY-2METHYL-5-(5-METHYLFUR-2-YL)-1H-BENZO[g]INDOLE | 2008 |
|
RU2368611C9 |
| METHOD FOR PREPARING DERIVATIVES OF 2-METHYL-5-(5-METHYL-2-FURYL)-4,10-DIHYDRO-3H-PYRIDAZINO[1,6-b]ISOQUINOLINE-10-ONE (VARIANTS) | 2006 |
|
RU2310653C1 |
| METHOD FOR PREPARATION OF DERIVATIVES OF PYRROLO[1,2-a][1,4]DIAZEPINE | 2006 |
|
RU2323939C1 |
| DERIVATIVES OF 3-AMINOMETHYLQUINOLONE-2 AS INHIBITORS OF NO-SYNTHETASE AND METHOD FOR THEIR PREPARING, BIOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2003 |
|
RU2267485C2 |
| METHOD FOR SYNTHESIS OF 4-(1H-INDOL-3-YL)-BUT-3-EN-2-ONE DERIVATIVES | 2009 |
|
RU2409564C1 |
| SELECTIVE ANTITUBERCULOSIS AGENT REPRESENTING 3-HYDRAZONO-6-(3,5-DIMETHYLPYRAZOL-1-YL)- 1,2,4,5-TETRAZINE AND METHOD FOR PREPARING IT | 2011 |
|
RU2479311C2 |
| METHOD FOR OBTAINING ALKYL-SUBSTITUTED 4-HALOGEN-3-HYDROXYFURO[3,4-c]PYRIDIN-1(3H)-ONES | 2015 |
|
RU2574412C1 |
| 4-SUBSTITUTED-3-(1-ALKYL-2-CHLORO-1H-INDOL-3-YL)FURAN-2,5-DIONES, SYNTHESIS METHOD THEREOF AND USE IN PHOTOCHEMICAL GENERATION OF STABLE FLUORESCENT COMPOUNDS AND 4,5-SUBSTITUTED-6-ALKYL-1H-FURO[3,4-c]CARBAZOLE-1,3(6H)-DIONES, SYNTHESIS METHOD THEREOF AND USE AS FLUOROPHORES | 2009 |
|
RU2396267C1 |
