FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of tetracyclic derivatives of isoquinolone. Invention describes a method for synthesis of derivatives of 3,5-dihydro-1,11-dimethylfuro[2',3':3,4]cyclohepta[c]isoquinoline-5-one of the general formula (1a-f): 
wherein (1a): R means hydrogen atom (H); R' means hydrogen atom (H); (1b): R means chlorine atom (Cl); R' means hydrogen atom (H); (1c): R means bromine atom (Br); R' means hydrogen atom (H); (1d): R means iodine atom (J); R' means hydrogen atom (H); (1e): R means methoxy-group (-OCH3); R' means hydrogen atom (H); (1f): R means -OCH3; R' means -OCH3. Method involves boiling derivatives of 3,5-dihydro-1,11-dimethylfuro[2',3':3,4]cyclohepta[c]isochromen-5-one in formamide medium in the ratio 0.01 mole of the parent substance per 45 ml of formamide for 25-120 min. Invention provides preparing new compounds that possess the potential useful biological properties.
EFFECT: improved method of synthesis, valuable properties of compounds.
2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 1,11-DIALKYL-3,5-DIHYDROFURO-[2',3':3,4]-CYCLOHEPTA[C]ISOCHROMENS | 2005 |
|
RU2282633C9 |
| METHOD FOR PREPARING DERIVATIVES OF 2-METHYL-5-(5-METHYL-2-FURYL)-4,10-DIHYDRO-3H-PYRIDAZINO[1,6-b]ISOQUINOLINE-10-ONE (VARIANTS) | 2006 |
|
RU2310653C1 |
| METHOD FOR PREPARATION OF DERIVATIVES OF PYRROLO[1,2-a][1,4]DIAZEPINE | 2006 |
|
RU2323939C1 |
| METHOD FOR SYNTHESIS OF 4-(1H-INDOL-3-YL)-BUT-3-EN-2-ONE DERIVATIVES | 2009 |
|
RU2409564C1 |
| METHOD OF PRODUCING 5,6-DIHYDRO-4H-FURO[2',3':3,4]CYCLOHEPTA[1,2-B]BENZOFURAN DERIVATIVES | 2015 |
|
RU2602822C1 |
| METHOD OF PRODUCING 1,2-DIHYDROPYRROLO[1,2-a]PYRAZIN-3(4H)-ONE DERIVATIVES | 2012 |
|
RU2490271C1 |
| 1',2',3'-TRIMETOXIBENZO[5',6:5,4]-1H-6,7-DIHYDROCYCLOGEPTA[3,2-f]BENZOFURAN DERIVATIVE AND ITS APPLICATION | 2015 |
|
RU2593998C1 |
| NOVEL CHEMICAL COMPOUNDS - 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVES FOR PREVENTING AND TREATING HUMAN AND ANIMAL DISEASES | 2012 |
|
RU2509770C2 |
| DERIVATIVES OF NOSCAPINE (VARIANTS), COMBINATORY AND FOCUSED LIBRARIES, PHARMACEUTICAL COMPOSITION, METHODS FOR THEIR PREPARING (VARIANTS) AND USING | 2006 |
|
RU2304584C1 |
| METHOD OF OBTAINING DERIVATIVES OF N-ACETYL-4-HYDROXY-2METHYL-5-(5-METHYLFUR-2-YL)-1H-BENZO[g]INDOLE | 2008 |
|
RU2368611C9 |
