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2 479 311

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IPC

A61K31/415(2006-01-01)

A61K31/4155(2006-01-01)

A61K31/15(2006-01-01)

A61K31/85(2006-01-01)

A61K31/135(2006-01-01)

A61K31/395(2006-01-01)

A61K31/137(2006-01-01)

A61K31/47(2006-01-01)

A61P31/06(2006-01-01)

C07B47/00(2006-01-01)

(21) (22)

Application

2011124593/15, 2011-06-17

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Start date

2011-06-17

(22)

Actual filing date

2011-06-17

(45)

Published

2013-04-20

(72)

Inventor

Rusinov Gennadij LeonidovichFedorova Ol'Ga Vasil'EvnaIshmetova Rashida IrshotovnaGanebnykh Il'Ja NikolaevichOvchinnikova Irina GeorgievnaKravchenko Marionella Anatol'EvnaCharushin Valerij Nikolaevich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Obrazovanija I Nauki Rossijskoj FederatsiiUchrezhdenie Rossijskoj Akademii Nauk Institut Organicheskogo Sinteza Im. I.Ja. Postovskogo Ural'Skogo Otdelenija Ran

SELECTIVE ANTITUBERCULOSIS AGENT REPRESENTING 3-HYDRAZONO-6-(3,5-DIMETHYLPYRAZOL-1-YL)- 1,2,4,5-TETRAZINE AND METHOD FOR PREPARING IT Russian patent published in 2013 - IPC A61K31/415 A61K31/4155 A61K31/15 A61K31/85 A61K31/135 A61K31/395 A61K31/137 A61K31/47 A61P31/06 C07B47/00

Abstract RU 2479311 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a selective antituberculosis agent representing 3-hydrazono-6-(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine of general formula A

wherein R₂ = hydrogen atom or methyl; R₃ = methyl, aryl specified in optionally substituted phenyl, heteryl specified in furyl, pyridyl, 3-phenylallyl. The invention also refers to a method for preparing 3-hydrazono-6-(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine with the use of microwave radiation; the given method is implemented with high speed and selectivity.

EFFECT: invention provides higher activity and specificity of antimycobacterial action.

2 cl, 3 tbl, 16 ex

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RU 2 479 311 C2

Authors

Rusinov Gennadij Leonidovich

Fedorova Ol'Ga Vasil'Evna

Ishmetova Rashida Irshotovna

Ganebnykh Il'Ja Nikolaevich

Ovchinnikova Irina Georgievna

Kravchenko Marionella Anatol'Evna

Charushin Valerij Nikolaevich

Dates

2013-04-20—Published

2011-06-17—Filed